Results 131 to 140 of about 8,985,595 (290)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Large deviations for stochastic predator–prey model with Lévy noise
Nonlinear AnalysisThis paper discusses the large deviations for stochastic predator–prey model driven by multiplicative Lévy noise. Using Galerkin approximation, we initially prove the existence and uniqueness of solution. Due to the equivalence between Laplace principle
C.S. Sridevi +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Exit times for some nonlinear autoregressive processes
Modern Stochastics: Theory and ApplicationsThe expected exit time from the interval $[-1,1]$ is investigated for an autoregressive process defined recursively by \[ {X_{n+1}^{\varepsilon }}=f\big({X_{n}^{\varepsilon }}\big)+\varepsilon {\xi _{n+1}},\hspace{1em}n=0,1,2,\dots ,\hspace{2.5pt}{X_ ...
Göran Högnäs, Brita Jung
doaj +1 more source
Multivariate Probabilities of Large Deviations
The Annals of Statistics, 1975 Let ${P_n}^{\infty_n=1}$ denote a sequence of probability measures on $(R^k,B^k)$, where $R^k$ is k-dimensional Euclidean space and $B^k$ the Borel subsets. For $A\inB^k$, let $e(A)=lim_{n\rigtharrow\infty}(1/n) log P_n(A)$, if the limit exists. Sufficient conditions are given for expressing e(A) as the supremum of e(B) for certain "rectangular" sets ...
openaire +3 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Computation of extreme heat waves in climate models using a large deviation algorithm. [PDF]
Proc Natl Acad Sci U S A, 2018 Ragone F, Wouters J, Bouchet F.
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Joint large deviation result for empirical measures of the coloured random geometric graphs. [PDF]
Springerplus, 2016 Doku-Amponsah K.
europepmc +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source