Results 211 to 220 of about 8,985,595 (290)

Zero-Shot Classification of Postoperative Complications From Real-World Discharge Letters According to the Clavien-Dindo System Using Large Language Models in Liver Surgery: Comparative Study. [PDF]

J Med Internet Res
Warmer S, Arzideh K, Morys M, Idrissi-Yaghir A, Bednarsch J, Heise D, Oezcelik A, Reschke M, Ulmer TF, Neumann UP, Nensa F, Borys K, Hosch R, Schmitz SM.   +13 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Subtyping Internet Gaming Disorder Based on Interindividual Deviation of Functional Connectivity: A Network Contingency Analysis. [PDF]

Addict Biol
Guo Y, Wang X, Li W, Lu G, Liu Y, Zhou S, Li K, Wang M, Lang Y, Zheng H, Zhang Y, Wang W.   +11 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Machine learning reveals structural determinants of odor detection thresholds and identifies high-potency food odorants. [PDF]

NPJ Sci Food
Hou X, Zhou Z, Shi P, Wang Y, Liu S, Ji Z, Zhang D, Mao J.   +7 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Irreversible vision loss following split lateral rectus nasal transposition for complete oculomotor nerve palsy. [PDF]

Am J Ophthalmol Case Rep
Komori M, Sato M, Arakawa A, Kaneko H, Hikoya A.   +4 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Accuracy of Dynamic and Static Navigated Endodontic Microsurgery Using Single Vertical Incision: A Retrospective Study. [PDF]

Int Dent J
Li X, Huang L, Li Y, Li S, Li X, Yang X.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source