Results 121 to 130 of about 13,006,447 (294)
Universal anomalous fluctuations in charged single-file systems
Physical Review ResearchIntroducing a general class of one-dimensional single-file systems (meaning that particle crossings are prohibited) of interacting hardcore particles with internal degrees of freedom (called charge), we exhibit a dynamical universality reflected in ...
Žiga Krajnik +4 more
doaj +1 more source
Analysis of the Rate Functions of Large Deviations for Symbol Statistics
J. Autom. Lang. Comb.Journal of Automata, Languages and Combinatorics, Volume 30, Numbers 1-3, 2025, 127 ...
M. Goldwurm, M. Vignati
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Large Deviation Principle For Functional Limit Theorems
, 2009 We study a family of stochastic additive functionals of Markov processes with locally independent increments switched by jump Markov processes in an asymptotic split phase space. Based on an averaging limit theorem, we obtain a large deviation result for
Oprisan, Adina
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Numerical estimation of limiting large-deviation rate functions
Physical Review EFor statistics of rare events in systems obeying a large-deviation principle, the rate function is a key quantity. When numerically estimating the rate function, one is always restricted to finite system sizes. Thus, if the interest is in the limiting rate function for infinite system sizes, first, several system sizes have to be studied numerically ...
Peter Werner, Alexander K. Hartmann
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Least absolute deviation estimation of linear econometric models: A literature review [PDF]
Econometricians generally take for granted that the error terms in the econometric models are generated by distributions having a finite variance. However, since the time of Pareto the existence of error distributions with infinite variance is known ...
Dasgupta, Madhuchhanda, Mishra, SK
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source