Results 91 to 100 of about 651,257 (303)

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

On some stochastic differential equations with jumps subject to small positives coefficients

open access: yesAIMS Mathematics, 2019
We provide a large deviation principle for jumps and stochastic diffusion processes, according to a viscosity coefficient (ε) and a small scaling parameter (δ) both going at the same rate. To do so we have to come up with estimates on the moment Lyapunov
Clement Manga   +2 more
doaj   +1 more source

Large Deviations in Fast–Slow Systems [PDF]

open access: green, 2016
Freddy Bouchet   +3 more
openalex   +1 more source

Nonlinear large deviations

open access: yesAdvances in Mathematics, 2016
We present a general technique for computing large deviations of nonlinear functions of independent Bernoulli random variables. The method is applied to compute the large deviation rate functions for subgraph counts in sparse random graphs. Previous technology, based on Szemeredi's regularity lemma, works only for dense graphs.
Chatterjee, Sourav, Dembo, Amir
openaire   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Large deviations for transient random walks with asymptotically zero drifts

open access: yesAIMS Mathematics
We consider transient nearest-neighbor random walks $ X: = \{X_{n}\}_{n\geq0} $ on the half-line, whose transition probabilities are state-dependent with certain asymptotic perturbations. This is a specific case of Lamperti's random walks. Let $ M_{t}: =
Hui Yang
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

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