Results 151 to 160 of about 727,226 (339)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Multivariate Probabilities of Large Deviations

open access: yesThe Annals of Statistics, 1975
Let ${P_n}^{\infty_n=1}$ denote a sequence of probability measures on $(R^k,B^k)$, where $R^k$ is k-dimensional Euclidean space and $B^k$ the Borel subsets. For $A\inB^k$, let $e(A)=lim_{n\rigtharrow\infty}(1/n) log P_n(A)$, if the limit exists. Sufficient conditions are given for expressing e(A) as the supremum of e(B) for certain "rectangular" sets ...
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Dynamical phase transitions, caustics, and quantum dark bands

open access: yesNew Journal of Physics
We provide a new perspective on quantum dynamical phase transitions (DPTs) by explaining their origin in terms of caustics that form in the Fock space representation of the many-body state over time, using the fully connected transverse field Ising model
Valentin Link   +2 more
doaj   +1 more source

Rogue waves and large deviations in deep sea. [PDF]

open access: yesProc Natl Acad Sci U S A, 2018
Dematteis G, Grafke T, Vanden-Eijnden E.
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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