Results 171 to 180 of about 727,226 (339)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
From Large Deviations to Semidistances of Transport and Mixing: Coherence Analysis for Finite Lagrangian Data. [PDF]
J Nonlinear Sci, 2018 Koltai P, Renger DRM.
europepmc +1 more source
Large deviations and slowdown asymptotics for one-dimensional excited random walks [PDF]
, 2012 Jonathon Peterson
openalex +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Lower Current Large Deviations for Zero-Range Processes on a Ring. [PDF]
J Stat Phys, 2017 Chleboun P +2 more
europepmc +1 more source
Large deviations for M-estimators
M-estimators, Maximum likelihood estimators, Large deviations, Empirical processes, Kullback–Leibler information,
Miguel Arcones
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Large deviations for nonlocal stochastic neural fields. [PDF]
J Math Neurosci, 2014 Kuehn C, Riedler MG.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Precise large deviations of aggregate claims in a size-dependent renewal risk model with stopping time claim-number process. [PDF]
J Inequal Appl, 2017 Zhang S, Wang D, Yu S.
europepmc +1 more source