Results 181 to 190 of about 727,226 (339)
Large deviations formalism for multifractals
For a wide class of measures, the multifractal spectrum is shown to exist iff an appropriate large deviations principle holds, in which case the spectrum is directly obtained from the corresponding rate function. A large deviations tool, enabling the use
Zohar, Gady
core
Estimating rank-one matrices with mismatched prior and noise: universality and large deviations
54 pagesInternational audienceWe prove a universality result that reduces the free energy of rank-one matrix estimation problems in the setting of mismatched prior and noise to the computation of the free energy for a modified Sherrington-Kirkpatrick ...
Ko, Justin +3 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
3D tamed Navier-Stokes equations driven by multiplicative Lévy noise: Existence, uniqueness and large deviations [PDF]
, 2018 Zhao Dong, Rangrang Zhang
openalex +1 more source
Large deviations for the smallest eigenvalue of a deformed GOE with an outlier
We establish a large deviation principle for the smallest eigenvalue of a random matrix model composed of the sum of a GOE matrix and a diagonal matrix with an outlier.
Boursier, Jeanne, Guionnet, Alice
core +1 more source
Large Deviation Results for the Nonparametric Regression Function\n Estimator on Functional Data [PDF]
, 2011 Djamal Louani +1 more
openalex +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
On large deviations of the empiric D. F. of vector chance variables and a law of the iterated logarithm [PDF]
, 1961 Jack Carl Kiefer
openalex +1 more source