Results 181 to 190 of about 651,257 (303)

Connections and causes of inter-model spread in boreal summer precipitation across monsoon regions in AMIP6 simulations. [PDF]

Sci Rep
Wen N, Huan K.
europepmc   +1 more source

Large Deviations, Dynamics and Phase Transitions in Large Stochastic and Disordered Neural Networks [PDF]

, 2013
Tanguy Cabana, Jonathan Touboul
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Feasibility of a Specialized Large Language Model for Postgraduate Medical Examination Preparation: Single-Center Proof-Of-Concept Study. [PDF]

JMIR Form Res
Leong YH, Nambiar L, Tay VYJ, Lie SA, Yuhe K.   +4 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A large deviations result for randomly interacting particle systems

, 2016
Tanguy Cabana, Jonathan Touboul
openalex   +1 more source

Large and moderate deviations principles for kernel estimators of the multivariate regression [PDF]

, 2007
Abdelkader Mokkadem, Mariane Pelletier, Baba Thiam   +2 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Under my umbrella: Rating scales obscure statistical power and effect size heterogeneity. [PDF]

Behav Res Methods
Fünderich JH, Beinhauer LJ, Renkewitz F.   +2 more
europepmc   +1 more source