Results 71 to 80 of about 159,850 (300)

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Evaluating the clinical effectiveness of repeat screening for gestational diabetes mellitus following a diagnosis of large for gestational age and/or polyhydramnios

Pregnancy
Objective Gestational diabetes mellitus (GDM) screening is often repeated in the third trimester when large for gestational age (LGA) and/or polyhydramnios are diagnosed. We evaluated outcomes for individuals who did versus did not rescreen, and also for
H. Tal Lesser, A. D. Mackeen, David Chromey, Amanda J. Young, Celia Gray, Michael J. Paglia   +5 more
doaj   +1 more source

Growth Abnormalities as a Risk Factor of Adverse Neonatal Outcome in Hypertensive Pregnancies—A Single-Center Retrospective Cohort Study

Children, 2021
(1) Background: Hypertensive disorders of pregnancy (HDP) include gestational hypertension (GH), chronic hypertension (CH), preeclampsia (PE), and preeclampsia superimposed on chronic hypertension (CH with PE).
Anna Kajdy, Stepan Feduniw, Jan Modzelewski, Dorota Sys, Dagmara Filipecka-Tyczka, Katarzyna Muzyka-Placzyńska, Paweł Kiczmer, Bartłomiej Grabowski, Michał Rabijewski   +8 more
doaj   +1 more source

Nonalcoholic fatty liver disease is a risk factor for large-for-gestational-age birthweight

, 2019
ObjectiveNonalcoholic fatty liver disease (NAFLD) is a well-recognized hepatic manifestation of metabolic disease in adults and has been associated with the development of gestational diabetes (GDM).
Won Kim, Ja Nam Koo (7309814), Chan-Wook Park, Sun Min Kim, Seung Mi Lee, Sue Shin, Sae Kyung Joo (4401715), Gyoung Min Kim, Sae Kyung Joo, Sang Youn Kim (6053744), Jong Kwan Jun, Jong Kwan Jun (7309832), Joong Shin Park (7309835), Chanthalakeo Vixa, Ig Hwan Oh, Soo Heon Kwak (7309826), Chanthalakeo Vixa (7309829), Byoung Jae Kim, Sue Shin (652479), Gyoung Min Kim (7309823), Ig Hwan Oh (7309820), Seung Mi Lee (317488), Byoung Jae Kim (7309811), Won Kim (437999), Errol R Norwitz, Soo Heon Kwak, Errol R. Norwitz (7309817), Ja Nam Koo, Joong Shin Park, Sun Min Kim (421876), Sang Youn Kim, Chan-Wook Park (317492)   +31 more
core   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Birth weight classification in gestational diabetes: is there an ideal chart?

Clinical and Biomedical Research, 2017
Introduction: Gestational diabetes mellitus (GDM) is associated to increased rates of large for gestational age newborns and macrosomia. Several charts are used to classify birth weight.
Livia Silveira Mastella, Letícia Schwertz Weinert, Vanessa Gnielka, Vânia Naomi Hirakata, Maria Lúcia Rocha Oppermann, Sandra Pinho Silveiro, Angela Jacob Reichelt   +6 more
doaj   +2 more sources

The timing of 40% oral dextrose gel administration after birth does not influence the incidence of hypoglycemia in at-risk infants

Global Pediatrics
Background: Hypoglycemia is the most common metabolic disorder seen in newborns and can cause long-term neurological damage, developmental disorders and poor later school performance.
De Bernardo Giuseppe, Giordano Maurizio, Langella Carmen, Piccirillo Daiana, Giada Zollo, Sordino Desiree, Morlino Francesca, Beretta Virginia, Perrone Serafina   +8 more
doaj   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Change of maternal weight gain trajectory following lifestyle interventions for gestational diabetes and its impact on abnormal infant birthweight: an observational study based on longitudinal weight measurements

BMC Pregnancy and Childbirth
Background Restricted gestational weight gain (GWG) following lifestyle interventions for gestational diabetes mellitus (GDM) has been observed in clinical trials but not been explicitly confirmed in real-world clinical settings.
Juan Li, Chuanzi Yang, Kuanrong Li
doaj   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source