Results 231 to 240 of about 7,342,884 (290)

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

A Novel Method to Localize Patency Capsule by Ileocolonoscopy Facilitates Endoscopic Assessment of the Small and Large Intestine in Patients with Crohn's Disease.

Digestion
Sonoda A, Mizukami K, Okano S, Nishiguchi T, Yamazaki D, Horie Y, Tateishi T, Saito Y, Hirose Y, Sano H, Saito S, Takazoe M, Iwamoto S, Sako M, Fukata M.   +14 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Carcinoids of the large intestine

Diseases of the Colon & Rectum, 1970
Twenty-two cases of carcinoid of the large intestine are presented. The pathology, clinical presentation and long-term results are reviewed. Eight of the 22 patients had evidence of nodal or distant spread and eight patients are known to have died of the disease, seven of the eight within five years of surgical operation.
F E, Rosato, J R, Anderson, P, Andrus
openaire   +2 more sources

Eicosanoids and the large intestine☆

Prostaglandins & Other Lipid Mediators, 2000
During the past three decades, many studies have been conducted to determine the precise role of eicosanoids in colorectal physiology and pathophysiology. This research has increased our understanding of bioactive lipid signaling, and may contribute to the development of more effective therapeutic modalities for digestive diseases in the future.
W, Krause, R N, DuBois
openaire   +2 more sources

ENDOMETRIOSIS OF THE SMALL AND LARGE INTESTINE

Obstetrical & Gynecological Survey, 1958
Summary A group of 12 cases of pelvic endometriosis involving the small intestine and bowel are presented. As pelvic endometriosis is most common between 25 and 40 years of age and is usually associated with infertility, it is of interest that the average age in this group was 40 years—the youngest patient being 23 years old and the oldest 52 years ...
R S, BOLES, P J, HODES
openaire   +2 more sources

Polyps of the large intestine

The American Journal of Surgery, 1951
Abstract 1. 1. Polyps of the large intestine are frequent. They are usually single but increase in number until in certain patients they become uncountable. 2. 2. Any polyp may develop into carcinoma. The more polyps, the greater tendency for carcinoma to form. 3. 3. All polyps should be removed. 4. 4.
openaire   +2 more sources