Results 31 to 40 of about 4,144,297 (347)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Large language models for bioinformatics

Quantitative Biology
Abstract With the rapid advancements in large language model technology and the emergence of bioinformatics‐specific language models (BioLMs), there is a growing need for a comprehensive analysis of the current landscape, computational characteristics, and diverse applications.
Wei Ruan, Yanjun Lyu, Jing Zhang 0010, Jiazhang Cai, Peng Shu, Yang Ge, Yao Lu, Shang Gao, Yue Wang, Peilong Wang, Lin Zhao 0004, Tao Wang, Yufang Liu, Luyang Fang, Ziyu Liu, Zhengliang Liu, Yiwei Li 0002, Zihao Wu 0001, Junhao Chen, Hanqi Jiang, Yi Pan 0001, Zhenyuan Yang, Jingyuan Chen, Shizhe Liang, Wei Zhang 0090, Terry Ma, Yuan Dou, Jianli Zhang, Xinyu Gong, Qi Gan, Yusong Zou, Zebang Chen, Yuanxin Qian, Shuo Yu, Jin Lu 0001, Kenan Song, Xianqiao Wang, Andrea Sikora, Gang Li 0001, Xiang Li 0001, Quanzheng Li, Yingfeng Wang, Lu Zhang 0050, Yohannes Abate, Lifang He 0001, Wenxuan Zhong, Rongjie Liu, Chao Huang 0005, Wei Liu 0146, Ye Shen, Ping Ma 0001, Hongtu Zhu, Yajun Yan, Dajiang Zhu, Tianming Liu 0001   +54 more
openaire   +3 more sources

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

On the creativity of large language models

AI & SOCIETY
Abstract Large language models (LLMs) are revolutionizing several areas of Artificial Intelligence. One of the most remarkable applications is creative writing, e.g., poetry or storytelling: the generated outputs are often of astonishing quality. However, a natural question arises: can LLMs be really considered creative?
Franceschelli, Giorgio, Musolesi, Mirco
openaire   +2 more sources

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

ChatLLM network: More brains, more intelligence

AI Open
Dialogue-based language models mark a huge milestone in the field of artificial intelligence, by their impressive ability to interact with users, as well as a series of challenging tasks prompted by customized instructions.
Rui Hao, Linmei Hu, Weijian Qi, Qingliu Wu, Yirui Zhang, Liqiang Nie   +5 more
doaj   +1 more source

Representation in large language models [PDF]

CoRR
The extraordinary success of recent Large Language Models (LLMs) on a diverse array of tasks has led to an explosion of scientific and philosophical theorizing aimed at explaining how they do what they do. Unfortunately, disagreement over fundamental theoretical issues has led to stalemate, with entrenched camps of LLM optimists and pessimists often ...
openaire   +3 more sources

A Survey of Large Language Models

CoRR, 2023
Language is essentially a complex, intricate system of human expressions governed by grammatical rules. It poses a significant challenge to develop capable AI algorithms for comprehending and grasping a language. As a major approach, language modeling has been widely studied for language understanding and generation in the past two decades, evolving ...
Wayne Xin Zhao, Kun Zhou 0002, Junyi Li 0001, Tianyi Tang, Xiaolei Wang 0005, Yupeng Hou, Yingqian Min, Beichen Zhang, Junjie Zhang 0009, Zican Dong, Yifan Du 0002, Chen Yang 0032, Yushuo Chen, Zhipeng Chen 0001, Jinhao Jiang, Ruiyang Ren, Yifan Li 0009, Xinyu Tang 0004, Zikang Liu 0001, Peiyu Liu 0002, Jian-Yun Nie, Ji-Rong Wen   +21 more
openaire   +2 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source