Results 61 to 70 of about 4,144,297 (347)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Text clustering with large language model embeddings

International Journal of Cognitive Computing in Engineering
Text clustering is an important method for organising the increasing volume of digital content, aiding in the structuring and discovery of hidden patterns in uncategorised data.
Alina Petukhova, João P. Matos-Carvalho, Nuno Fachada   +2 more
doaj   +1 more source

On the Thinking-Language Modeling Gap in Large Language Models

CoRR
System 2 reasoning is one of the defining characteristics of intelligence, which requires slow and logical thinking. Human conducts System 2 reasoning via the language of thoughts that organizes the reasoning process as a causal sequence of mental language, or thoughts.
Chenxi Liu, Yongqiang Chen 0002, Tongliang Liu, James Cheng, Bo Han 0003, Kun Zhang 0001   +5 more
openaire   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Radiology-GPT: A large language model for radiology

Meta-Radiology
We introduce Radiology-GPT, a large language model for radiology. Using an instruction tuning approach on an extensive dataset of radiology domain knowledge, Radiology-GPT demonstrates superior performance compared to general language models such as ...
Zhengliang Liu, Yiwei Li, Peng Shu, Aoxiao Zhong, Hanqi Jiang, Yi Pan, Longtao Yang, Chao Ju, Zihao Wu, Chong Ma, Cheng Chen, Sekeun Kim, Haixing Dai, Lin Zhao, Lichao Sun, Dajiang Zhu, Jun Liu, Wei Liu, Dinggang Shen, Quanzheng Li, Tianming Liu, Xiang Li   +21 more
doaj   +1 more source

Scalable watermarking for identifying large language model outputs

Nature
Large language models (LLMs) have enabled the generation of high-quality synthetic text, often indistinguishable from human-written content, at a scale that can markedly affect the nature of the information ecosystem1–3.
Sumanth Dathathri, Abigail See, Sumedh Ghaisas, Po-Sen Huang, R. McAdam, Johannes Welbl, Vandana Bachani, Alex Kaskasoli, Robert Stanforth, Tatiana Matejovicova, Jamie Hayes, Nidhi Vyas, Majd Al Merey, Jonah Brown-Cohen, Rudy Bunel, Borja Balle, taylan. cemgil, Zahra Ahmed, Kitty Stacpoole, Ilia Shumailov, Cip Baetu, Sven Gowal, D. Hassabis, Pushmeet Kohli   +23 more
semanticscholar   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Reverse synthesis of natural language phrases grounding on their ontological representation using a large language model [PDF]

The presented article introduces a novel solution that uses a specially developed structured prompt for a large language model (Chat GPT). A series of experiments were carried out on synthesizing natural language phrases based on their ontological ...
Kaverynskyi, V.V., Litvin, A.A., Palagin, O.V.   +2 more
core  

Reverse Modeling in Large Language Models

Proceedings of the 2025 Conference of the Nations of the Americas Chapter of the Association for Computational Linguistics: Human Language Technologies (Volume 2: Short Papers)
Humans are accustomed to reading and writing in a forward manner, and this natural bias extends to text understanding in auto-regressive large language models (LLMs). This paper investigates whether LLMs, like humans, struggle with reverse modeling, specifically with reversed text inputs.
Sicheng Yu, Yuanchen Xu, Cunxiao Du, Yanying Zhou, Minghui Qiu, Qianru Sun, Hao Zhang, Jiawei Wu   +7 more
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source