Results 81 to 90 of about 2,420,708 (306)

Large language models (ChatGPT) in medical education: Embrace or abjure?

The Asia Pacific Scholar, 2023
Nathasha Luke, Reshma Taneja, Kenneth Ban, Dujeepa Samarasekera, Celestial T Yap   +4 more
doaj   +1 more source

Can large language models understand molecules?

BMC Bioinformatics
Purpose Large Language Models (LLMs) like Generative Pre-trained Transformer (GPT) from OpenAI and LLaMA (Large Language Model Meta AI) from Meta AI are increasingly recognized for their potential in the field of cheminformatics, particularly in ...
Shaghayegh Sadeghi, Alan Bui, Ali Forooghi, Jianguo Lu, Alioune Ngom   +4 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Uncertainty quantification by large language models

Machine Learning with Applications
As reasoning capabilities of large language models (LLMs) continue to advance, they are being integrated into increasingly complex scientific workflows, with the goal of developing agents capable of generating evidence-based explanations and testing ...
Dorianis M. Perez, Bryan E. Kaiser, Ismael Boureima   +2 more
doaj   +1 more source

Sabiá: Portuguese Large Language Models

, 2023
As the capabilities of language models continue to advance, it is conceivable that "one-size-fits-all" model will remain as the main paradigm. For instance, given the vast number of languages worldwide, many of which are low-resource, the prevalent practice is to pretrain a single model on multiple languages.
Ramon Pires, Hugo Abonizio, Thales Sales Almeida, Rodrigo Nogueira   +3 more
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Ensemble Large Language Models: A Survey

Information
Large language models (LLMs) have transformed the field of natural language processing (NLP), achieving state-of-the-art performance in tasks such as translation, summarization, and reasoning.
Ibomoiye Domor Mienye, Theo G. Swart
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Large language models in critical care

Journal of Intensive Medicine
The advent of chat generative pre-trained transformer (ChatGPT) and large language models (LLMs) has revolutionized natural language processing (NLP).
Laurens A. Biesheuvel, Jessica D. Workum, Merijn Reuland, Michel E. van Genderen, Patrick Thoral, Dave Dongelmans, Paul Elbers   +6 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source