Results 71 to 80 of about 644,703 (262)

Large mode area fiber lasers and their applications [PDF]

Advanced Solid State Lasers, 2000
The area of fiber lasers has undergone rapid developments in recent years. Gone are the days when fiber lasers were seen as something of an irrelevant curiosity, offering interesting performance features, but always with power levels or other performance limitations, that made them unsuitable for all but a few applications.
Richardson, D.J., Offerhaus, H.L., Broderick, N.G.R.   +2 more
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Optical Mode Calculation in Large-Area Photonic Crystal Surface-Emitting Lasers

IEEE Photonics Journal
We discuss algorithms and numerical challenges in constructing and resolving spectral problems for photonic crystal surface-emitting lasers (PCSELs) with photonic crystal layers and large (up to several tens of mm$^{2}$) emission areas.
Mindaugas Radziunas, Eduard Kuhn, Hans Wenzel, Ben King, Paul Crump   +4 more
doaj   +1 more source

Single-Mode Operation in Flat Fibers Slab Waveguide via Modal Leakage

IEEE Photonics Journal, 2017
An approach to obtain single-mode operation on a semirectangular large core area Flat Fiber (FF) slab waveguide is proposed. A new design of FF with two defect eye holes is presented, and its single-mode guiding is analyzed by simulation. To validate the
Soo Yong Poh, Ghafour Amouzad Mahdiraji, Yong Meng Sua, Fatemeh Amirkhan, Din Chai Tee, Kwok Shien Yeo, Faisal Rafiq Mahamd Adikan   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Direct measurement of bend-induced mode deformation in large-mode-area fibers

Optics Express, 2012
In 1976 Marcuse developed an equivalent index model to predict the effects of bending in waveguides, and predicted deformation of the spatial modes in bent optical fibers. Perturbative approaches have been previously applied and tested to predict the behavior of single- and few-moded-fibers.
R C G, Smith, A M, Sarangan, Z, Jiang, J R, Marciante   +3 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Large mode area photonic crystal fibre

Electronics Letters, 1998
The authors report the realisation of a new design for a large mode area monomode optical fibre. This photonic crystal fibre will guide only a single mode, no matter how large the fibre diameter, provided the shape is kept constant. This is demonstrated with a fibre which has a core diameter equal to approximately 50 free-space wavelengths.
Knight, J.C., Birks, T.A., Cregan, R.F., Russell, P.St.J., de Sandro, J.P.   +4 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source