Results 111 to 120 of about 4,498,304 (271)
Determination of fracture toughness parameter of large metal structures Industrial review [PDF]
Fracture toughness and resistance determined for large steel structures using stress intensity calculations - fracture ...
Wahl, A. M.
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Learning from topology: cosmological parameter estimation from the large-scale structure
Machine Learning: Science and TechnologyThe topology of the large-scale structure of the Universe contains valuable information on the underlying cosmological parameters. While persistent homology can extract this topological information, the optimal method for parameter estimation from the ...
Jacky H T Yip +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Electromagnetic transmission problems with a large parameter in weighted Sobolev spaces
Electronic Journal of Differential Equations, 2013 We present an a priori estimate for an electromagnetic transmission problem in unbounded exterior domains in R^3. We consider Maxwell's equations in two sub-domains, the bounded interior representing a conducting material (metal) and the unbounded ...
Jorge Eliecer Ospino
doaj
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Geometric Parameter Identification of Large Bent Pipes Using a Single-View Vision System
SensorsThis paper describes methods of determining important measurement parameters of large bent pipes with diameters of up to 1.2 m for heavy industry, which can be obtained instantly from a vision system.
Krzysztof Borkowski +3 more
doaj +1 more source
Nuisance parameters for large galaxy surveys
, 2016 These notes are based on a lecture given at the 2016 Euclid Summer School in Narbonne. I will first give a quick overview of the concept of nuisance parameters in the context of large galaxy surveys. The second part will examine the case study of intrinsic alignments, a potential important contamination of weak lensing observables.
openaire +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source