Results 81 to 90 of about 4,498,304 (271)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Cross section, final spin and zoom-whirl behavior in high-energy black hole collisions

open access: yes, 2009
We study the collision of two highly boosted equal mass, nonrotating black holes with generic impact parameter. We find such systems to exhibit zoom-whirl behavior when fine tuning the impact parameter.
E. Witten   +9 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Darwin Meets Einstein: LISA Data Analysis Using Genetic Algorithms

open access: yes, 2006
This work presents the first application of the method of Genetic Algorithms (GAs) to data analysis for the Laser Interferometer Space Antenna (LISA). In the low frequency regime of the LISA band there are expected to be tens of thousands galactic binary
C. Darwin   +5 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Error Analysis and Parameter Recommendations for Randomness Test Under Large Sample Conditions [PDF]

open access: yesJisuanji kexue
In the field of information security,randomness tests play a crucial role in ensuring the security of cryptographic systems.The stability and reliability of these tests directly impact the overall security of cryptographic systems,making error issues ...
SUN Yueyue, FAN Limin
doaj   +1 more source

Large Scale Inhomogeneities from the QCD Phase Transition

open access: yes, 1994
We examine the first-order cosmological QCD phase transition for a large class of parameter values, previously considered unlikely. We find that the hadron bubbles can nucleate at very large distance scales, they can grow as detonations as well as ...
A. Guth   +24 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

On parameter identification for large space structures [PDF]

open access: yes
The design of a controller for large space structures (LSS) based on the LQG theory requires the knowledge of the LSS parameters. Since apriori knowledge of the parameters is usually not reliable, the parameters must be identified prior to the controller
Goglia, G. L., Joshi, S. M.
core   +1 more source

Three-Loop Electroweak Correction to the Rho Parameter in the Large Higgs Mass Limit

open access: yes, 2004
We present an analytical calculation of the leading three-loop radiative correction to the rho-parameter in the Standard Model in the large Higgs mass limit.
Akhoury   +30 more
core   +2 more sources

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