Results 91 to 100 of about 219,084 (199)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
An accurate map of Cardigan Shire [cartographic material] : An accurate map of Pembroke Shire /
Maps of Cardiganshire and Pembrokeshire showing principal towns and roads with relief shown pictorially.; Prime meridian: London.; Map imprint: Printed for Carington Bowles in St. Pauls Church Yard, Robt. Sayer in Fleet Street & Robt.
Bowen, Emanuel, d. 1767.
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Bayesian Design and Analysis of Small Multifactor Industrial Experiments
, 2011 PhDUnreplicated two level fractional factorial designs are a common type of experimental design used in the early stages of industrial experimentation.
Kapoor, Deepa
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Map of counties of Cumberland and Westmoreland showing principal towns and roads with relief shown pictorially.; Prime meridian: London.; Map imprint: Printed for T. Bowles in St. Pauls Church Yard, Robt.
Bowen, Emanuel, d. 1767.
core
, 2007 Grafiksel t-tasarımları, kombinatöryel tasarımlar sınıfına girer ve tasarım teorisinin en önemli yapılarıdır. Bu tasarımlar istatistiksel deneylerde yapı maliyetlerini minimum yapmada önemlidir.
KARABACAK, AYLİN
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