Results 81 to 90 of about 219,084 (199)

Thermal-aware SoC test scheduling with test set partitioning and interleaving

, 2006
High temperature has become a major problem for system-on-chip testing. In order to reduce the test application time while keeping the temperatures of the cores under test within safe ranges, a thermal-aware test scheduling technique is required.
Peng, Zebo, Rosinger, P, Zhiyuan He, Eles, Petru,, Zhiyuan, He, Al-Hashimi, Bashir M., Al-Hashimi, Bashir, Paul Rosinger, Al-Hashimi, BM, Zebo Peng, He, ZY, Peng, Z, Peng, Zebo,, Eles, Petru, Rosinger, Paul, Rosinger, Paul,, Peng, Zepo, Eles, P, Bashir M. Al-hashimi, Zhiyuan, He,, Al-Hashimi, Bashir,, Petru Eles   +21 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Supersaturated designs: set-ups, data interpretation, and analytical applications.

, 2008
For screening purposes, two-level screening designs, such as fractional factorial (FF) and Plackett-Burman (PB) designs, are usually applied. These designs enable examination of, at most, N-1 factors in N experiments.
Dejaegher, Bieke, Vander Heyden, Yvan
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Large emergency-response exercises: qualitative characteristics - a survey

, 2009
Exercises, drills, or simulations are widely used, by governments, agencies and commercial organizations, to simulate serious incidents and train staff how to respond to them. International cooperation has led to increasingly large-scale exercises, often
Julia Upton, Peter Trim, Lee, Y.I., Trim, P.R.J., Yang-im Lee, Lee, Yang-im, David Upton, Upton, J., Upton, D., Trim, Peter R.J.   +9 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Transcription Factors T-bet and GATA-3 Control Alternative Pathways of T-cell Differentiation Through a Shared Set of Target Genes

, 2009
Upon detection of antigen, CD4+ T helper (Th) cells can differentiate into a number of effector types that tailor the immune response to different pathogens.
Jackson, Ian, Sun, Kaiming, Young, Richard A., Glimcher, Laurie H., Young, R. A., Lord, G. M., Jenner, Richard G., Townsend, M. J., Sun, K., Townsend, Michael J., Jackson, I., Bouwman, R. D., Bouwman, Russell D., Jenner, R. G., Lord, Graham M., Glimcher, L. H.   +15 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Theory and Construction Methods for Large Regular Resolution IV Designs

, 2003
We define 2k-p fractional factorial designs which use all of their degrees of freedom to estimate main effects and two-factor interactions as second order saturated (sos) designs.
Block, Robert M.
core