Results 31 to 40 of about 219,084 (199)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Geometric construction of optimal designs for dose-responsemodels with two parameters [PDF]
In dose-response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We derive optimal designs for estimating the underlying dose-response curve for a restricted or unrestricted dose range with respect to a ...
Zhu, Wei +2 more
core
More on halving the complete designs
, 1994 A large set of disjoint S(λ; t, k, v) designs, denoted by LS(λ; t, k, v), is a partition of k-subsets of v-set into S(λ; t, k, v) designs. In this paper, we develop some recursive methods to construct large sets ot t-designs.
Khosrovashahi, G.B., Ajoodani-Namini, S.
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Large Sets of Disjoint t-Designs
, 1996 In this paper, we show how the basis reduction algorithm of Kreher and Radziszowski [4] can be used to construct large sets of disjoint designs with specified automorphisms.
Donald L. Kreher +3 more
core
Using integer programming in finding t-designs [PDF]
, 2012 A t-design is a combinatorial structure consisting of a collection of blocks over a set of points satisfying certain properties. The existence of t-designs given a set of parameters can be reduced to finding nonnegative integer solutions to a given ...
Chung, Kelvin
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Optimal designs for dose-response models with restricted design spaces [PDF]
In dose response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We present restricted and unrestricted interval locally optimal designs with respect to a very general class of optimality criteria for ...
Zhu, Wei +2 more
core
Partially Balanced 3-Designs using Mutually Orthogonal Latin Squares
, 2022 Not Availablet-designs represent a generalized class of balanced incomplete block designs in which the number of blocks in which any t treatments (t 2) occur together is a constant.
Cini Varghese +4 more
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source