Results 41 to 50 of about 219,084 (199)

Comparison of Outlier Detection Methods in Crossover Design Bioequivalence Studies

open access: yes, 2013
The significance of bioequivalence (BE) studies is rising due to large scale production and utilization of generic products all over the world. The correct identification of outlying data in BE studies is substantial for deciding two products either ...
T. Ahmad, Rasheed, J.S. Siddiqi
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Experimental designs for environmental valuation with choice-experiments: A Monte Carlo investigation

open access: yes, 2005
We review the practice of experimental design in the environmental economics literature concerned with choice experiments. We then contrast this with advances in the field of experimental design and present a comparison of statistical efficiency across ...
RICCARDO SCARPA   +2 more
core  

t-Designs from the large Mathieu groups

open access: yes, 1981
A t-design (X, B) is a υ-set X together with a family B of k-subsets from X, called blocks, such that each subset of X of size t is contained in exactly λ members of B. A t-design with the above parameters is also called a t-(υ, k, λ)design.
Magliveras, Spyros S.   +2 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

On Minimal Defining Sets of Full Designs and Self-Complementary Designs, and a New Algorithm for Finding Defining Sets of t-Designs

open access: yes, 2010
A defining set of a t-(v, k, lambda) design is a partial design which is contained in a unique t- design with the given parameters. A minimal defining set is a defining set, none of whose proper partial designs is a defining set.
Yazici, Emine Sule, Kolotoglu, Emre
core   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Search for top quark decays t → qH with H → γγ using the ATLAS detector [PDF]

open access: yes, 2014
A search is performed for flavour-changing neutral currents in the decay of a top quark to an up-type (c, u) quark and a Higgs boson, where the Higgs boson decays to two photons.
G. Khoriauli   +999 more
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

open access: yesFEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez   +2 more
wiley   +1 more source

On properties and constructions of t -designs, lambda -designs and perpendicular arrays

open access: yes, 1991
Combinatorial configurations have significant applications in many areas, such as in the design of experiments, coding theory, computer architecture, and information storage and retrieval. In this work, we will concentrate on three types of combinatorial
Wu, Qiu-rong
core  

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