Results 131 to 140 of about 1,247,248 (314)

Harnessing AI in School Counselling: Exploring the Potential of ChatGPT for Student Support

Educational Process: International Journal
Background/purpose. This study explores the extent to which ChatGPT, an AI-powered large language model, can support school counseling services in addressing students’ academic, social, and emotional needs, considering student AI literacy and adoption.
Ahmad Al-shraifin, Yousef Wardat, Rommel AlAli, Khaled Al-Saud   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Global solution with partial large initial data to the Keller–Segel–Navier–Stokes equations in Besov spaces

Journal of Inequalities and Applications
In this paper, we prove a global large solution result to the Keller–Segel–Navier–Stokes equations in critical Besov spaces. The result indicates that the global solutions exist without any small conditions imposed on the initial oxygen concentration c 0
Xuhuan Zhou
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Regularity of large solutions for the compressible magnetohydrodynamic equations

Boundary Value Problems, 2011
In this paper, we consider the initial-boundary value problem of one-dimensional compressible magnetohydrodynamics flows. The existence and continuous dependence of global solutions in H 1 have been established in Chen and Wang (Z Angew Math Phys 54, 608-
Qin Yuming, Peng Xiaozhen, Liu Xin
doaj  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Beyond simulation: designing for uncertainty and robust solutions

, 2010
Simulation is an increasingly essential tool in the design of our environment, but any model is only as good as the initial assumptions on which it is built.
Hesselgren, L, Gonzalez, V, Hanna, S, Vargas, I   +3 more
core  

Infinitely many large energy solutions of superlinear Schrodinger-Maxwell equations

Electronic Journal of Differential Equations, 2012
In this article we study the existence of infinitely many large energy solutions for the superlinear Schrodinger-Maxwell equations $$displaylines{ -Delta u+V(x)u+ phi u=f(x,u) quad hbox{in }mathbb{R}^3,cr -Delta phi=u^2, quad hbox{in }mathbb{R}^3, }
Lin Li, Shang-Jie Chen
doaj  

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source