Results 131 to 140 of about 10,005,809 (327)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

One-dimensional adhesion model for large scale structures

open access: yesElectronic Journal of Differential Equations, 2010
We discuss initial value problems and initial boundary value problems for some systems of partial differential equations appearing in the modelling for the large scale structure formation in the universe.
Kayyunnapara Thomas Joseph
doaj  

COMPUTATIONAL EFFECTIVENESS OF LMI DESIGN STRATEGIES FOR VIBRATION CONTROL OF LARGE STRUCTURES [PDF]

open access: gold, 2016
Francisco Palacios   +3 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Design and Structural Analysis of the Modular Post-Tensioned Steel Structure for Halls 3, 4 and 6 of Fira de la Gran Vía in Barcelona

open access: yesEng
This article presents the design process and structural analysis for Halls 3, 4, and 6 commissioned by Fira de la Gran Vía in Barcelona. Its objective is to document the complete development of a real structure—from the initial briefing to final ...
Ignacio Costales Calvo   +3 more
doaj   +1 more source

Quantized electronic fine structure with large anisotropy in ferromagnetic Fe films [PDF]

open access: green, 2014
Christoph Seibel   +6 more
openalex   +1 more source

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