Results 111 to 120 of about 15,790,105 (302)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Brain structure-function associations identified in large-scale neuroimaging data

, 2016
The relationships between structural and functional measures of the human brain remain largely unknown. A majority of our limited knowledge regarding structure-function associations has been obtained through comparisons between specific groups of ...
Liu, Rui, Qiu, Jiang, Zuo, Xi-Nian, Wang, Peipei, Xi-Nian Zuo, Zhi Yang, Yang, Zhi   +6 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Influence of human pressures on large river structure and function [PDF]

, 2009
A large river study was conducted as part of the Cross Departmental Research Pool (CDRP) ecological integrity project to (i) provide an overview of the macroinvertebrate faunas of large rivers, including those in deep-water habitats, and (ii) to ...
Clapcott, Joanne E., Collier, Kevin J., Young, Roger G.   +2 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Large x behaviour and the non-perturbative structure of hadronic systems

, 2005
While the traditional interest in structure functions has been the confirmation of the predictions of perturbative QCD, this data also contains a wealth of information on how QCD works in the infrared, or confinement, region.
Thomas, A.
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Large–scale structure and matter in the Universe

Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences, 2003
17 Pages. Review paper from the January 2003 Royal Society Discussion Meeting, "The search for dark matter and dark energy in the universe"
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Curvature-Influenced Electrocatalytic NRR Reactivity by Heme-like FeN₄-Site on Carbon Materials

Molecules
Two-dimensional carbon materials and their derivatives are widely applied as promising electrocatalysts and supports of single-atom sites. Theoretical investigations of 2D carbon materials are usually based on planar models, yet ignore local curvature ...
Yajie Meng, Ziyue Huang, Xi Chen, Yingqi Li, Xueyuan Yan, Jiawei Xu, Haiyan Wei   +6 more
doaj   +1 more source