Results 161 to 170 of about 15,790,105 (302)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Flexible Structure Large Deformation and Large Motion Fluid-structure Interaction Simulation Method

工程科学与技术
Objective To accurately characterize the large deformation and large motion behavior of flexible structures interacting with fluid flows, a hybrid numerical method integrating computational fluid dynamics (CFD), the nonlinear finite element method (FEM),
MAO Jia, XIA Zongyao, LI Feng, ZHAO Lanhao   +3 more
doaj  

Laparoscopic diverticulectomy and ureteric reimplantation for congenital bladder diverticulum. [PDF]

J Surg Case Rep
Costa C, Dastidar A, Rijhwani A, Chakraborty S, Moniati F, Dzhuma K.   +5 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Gene Structure Assembly Through Analysis of Large-Scale ESTs

, 2009
[[abstract]]The Gene Structure Contains Promoter, EXON, INTRON, Polyadenylation Tail, 5' Untranslated Region, 3' Untranslated Region and open reading frame.
Jiun-Tang You
core  

Laparoscopic excision of a large prostatic utricle in an infant with 46,xx Sry-negative differences of sex development: a case report. [PDF]

J Surg Case Rep
Costa C, Dastidar A, Rijhwani A, Ryan F, Shears D, Owen M, Chakraborty S, Moniati F, Dzhuma K.   +8 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Reply to: Letter "what defines an anatomic structure?" on "The Cuneus Vein: Initial Anatomical Description and Preservation Technique for Posterior Interhemispheric Approaches". [PDF]

Acta Neurochir (Wien)
Gurses ME, Gungor A, Uğur Türe.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation. [PDF]

iScience
Li Y, Zhao Y, Sonmez K, Giancardo L, Guo L, Hong P, Cheng N, Yilmaz M.   +7 more
europepmc   +1 more source