Results 151 to 160 of about 148,150 (347)
Functional Outcome, Recanalization, and Hemorrhage Rates After Large Vessel Occlusion Stroke Treated With Tenecteplase Before Thrombectomy
, 2021 Gaspard Gerschenfeld, Didier Smadja, Guillaume Turc, Stéphane Olindo, François-Xavier Laborne, Marion Yger, Jildaz Caroff, Bruno Gonçalves, Pierre Seners, Marie Cantier, Y. L’hermitte, Manvel Aghasaryan, Cosmin Alecu, Gaultier Marnat, Wagih Ben Hassen, Erwah Kalsoum, Frédéric Clarençon, Michel Piotin, Laurent Spelle, Christian Denier, Igor Sibon, Sonia Alamowitch, Nicolas Chausson, Vincent Degos, Mariana Sarov, Nicolas Legris, Olivier Chassin, Djibril Soumah, Tony Altarcha, Carole Imbernon, Pauline Renou, Mathilde Poli, Sabrina Debruxelles, Sharmila Sagnier, François Rouanet, Jean-Sébastien Liegey, David Calvet, Jean‐Claude Baron, Laure Bottin, Stephen Delorme, Jean Capron, Diana Doukhi, Sam Ghazanfari, David Weisenburger, Edwige Lescieux, Florent Gariel, Xavier Barreau, Patrice Ménégon, Thomas Tourdias, Catherine Oppenheim, Olivier Naggara, Titien Tuilier, Nader Sourour, Nader Sourour, Eimad Shotar, Stéphanie Lenck, Kévin Premat, Raphaël Blanc, Simon Escalard, Robert Fahed, Stanislas Smajda, Mikaël Mazighi, Mikael Mazighi +62 moreopenalex +2 more sourcesTargeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A‐IGF2BP1 for Ischemic Stroke Rescue
Advanced Science, EarlyView.Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...Ling Li, Yong‐Dong Guo, Xiao‐Wen Zhang, Zhi‐Yong Du, Yu‐Qi Wang, Zhuo Yang, Qian‐Wei Luo, Fang‐Fang Zhuo, Tian‐Tian Wei, Zheng‐Ping Liu, Bo Han, Wei Yu, Pei‐Pei Zhang, Wei Zhou, Zhi‐Yuan Lu, Peng‐Fei Tu, Chun‐Hong Zheng, Ke‐Wu Zeng +17 morewiley +1 more sourceBio‐Inspired Micro‐Fin‐Assisted Multi‐Modal Vascular Intervention
Advanced Science, EarlyView.A magnetic guidewire with a micro‐fin–integrated tip is introduced for multimodal cardiovascular navigation. The micro‐fins exploit fluid drag to augment magnetic torque, enabling bifurcation traversal at 15 mT, tolerating 45° misalignment, bidirectional crawling, and buckle self‐correction.Xu Liu, Qiang Luo, Zhuoqun Cao, Hongde Li, Xi Chen, Hong Wang, Mao Chen, Ziyu Ren, Wenqi Hu +8 morewiley +1 more sourceTargeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias
Advanced Science, EarlyView.Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang +32 morewiley +1 more sourcePOST‐UK (Adjunctive Intra‐Arterial Urokinase After Successful Endovascular Thrombectomy in Patients With Large‐Vessel Occlusion Stroke): Study Protocol of a Multicenter, Prospective, Randomized, Open‐Label, Blinded‐End Point Trial
Stroke: Vascular and Interventional NeurologyBackground Intra‐arterial infusion of an adjunctive thrombolytic agent after macrovascular recanalization by endovascular thrombectomy was regarded as a promising strategy to promote outcomes of patients with stroke.Chang Liu, Fengli Li, Jiaxing Song, Xu Xu, Jiacheng Huang, Changwei Guo, Weilin Kong, Jie Yang, Xiaolei Shi, Jinfu Ma, Shihai Yang, Zhixi Wang, Shitao Fan, Liu Xiang, Sun Wenzhe, Nizhen Yu, Chengsong Yue, Zhouzhou Peng, Linyu Li, Cheng Huang, Dahong Yang, Duolao Wang, Jeffrey Saver, Thanh N. Nguyen, Raul G. Nogueira, Yangmei Chen, Wenjie Zi +26 moredoaj +1 more sourceEndothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis
Advanced Science, EarlyView.This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu +10 morewiley +1 more sourcePredictors and clinical relevance of hemorrhagic transformation after endovascular therapy for anterior circulation large vessel occlusion strokes: a multicenter retrospective analysis of 1122 patients [PDF]
, 2014 Raul G. Nogueira, Rishi Gupta, Tudor G. Jovin, Elad I. Levy, David S. Liebeskind, Osama O. Zaidat, Ansaar Rai, Joshua A Hirsch, Daniel P. Hsu, Marilyn M. Rymer, Ashis Tayal, Ridwan Lin, Sabareesh K. Natarajan, Ashish Nanda, Melissa Tian, Qing Hao, Junaid Kalia, Michael Chen, Alex Abou‐Chebl, Thanh N. Nguyen, Albert J. Yoo +20 moreopenalex +1 more sourceNeuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia‐Reperfusion Injury
Advanced Science, EarlyView.Cerebral ischemia‐reperfusion injury (CIRI) is a key pathological process limiting the efficacy of stroke therapy. This study has developed an innovative, multifunctional, brain‐targeted nanoplatform (RFP) containing MXene nanoenzymes and ferroptosis inhibitors.Lu Wang, Chao Hou, Shuo Li, Lizhi Yang, Yiqun Lin, Sen Wang, Xiaohua Jia, Hui Hui, Wen He, Wei Zhang +9 morewiley +1 more source
