Results 81 to 90 of about 333,893 (395)

Focused update to guidelines for endovascular therapy for emergent large vessel occlusion: basilar artery occlusion patients

Journal of NeuroInterventional Surgery
Background Endovascular therapy (EVT) dramatically improves clinical outcomes for patients with anterior circulation emergent large vessel occlusion (ELVO) strokes.
J. Heit, Neeraj Chaudhary, J. Mascitelli, Mais Al-Kawaz, Amanda Baker, K. Bulsara, J. Burkhardt, Franklin A. Marden, D. Raper, S. Tjoumakaris, C. Schirmer, S. Hetts   +11 more
semanticscholar   +1 more source

Late Window Imaging Selection for Endovascular Therapy of Large Vessel Occlusion Stroke: An International Survey

Stroke: Vascular and Interventional Neurology, 2022
Current stroke guidelines recommend advanced imaging (computed tomography [CT] perfusion or magnetic resonance imaging) prior to endovascular therapy (EVT) in patients with late presentation of large vessel occlusion.
Thanh N. Nguyen, P. Klein, A. Berberich, S. Nagel, M. Abdalkader, Ana Herning, Yimin Chen, X. Huo, Z. Miao, Sunil A. Sheth, Muhammad M. Qureshi, J. Siegler, S. Sacco, D. Strbian, U. Fischer, H. Yamagami, E. Kristoffersen, V. Puetz, W. Schonewille, G. Tsivgoulis, B. Drumm, Soma Banerjee, J. Demeestere, F. Alemseged, E. Sandset, A. Arsovska, K. Krishnan, P. Dhillon, Angel Corredor, R. Rivera, P. Šedová, R. Mikulík, H. Masoud, S. Martins, T. H. Nguyen, M. D. Ton, Xinfeng Liu, Yuyou Zhu, Fengli Li, W. A. W. Zaidi, M. Zedde, S. Yaghi, J. Miao, V. Inoa, Liqun Zhang, R. Masiliūnas, P. Slade, S. Matuja, J. Marto, P. Michel, J. Fiehler, G. Thomalla, A. Castonguay, M. Mokin, M. Parsons, B. Campbell, D. Yavagal, D. Dippel, M. Goyal, O. Zaidat, T. Jovin, Wei Hu, R. Nogueira, Zhongming Qiu, Jean-Philippe Raymond, G. Saposnik   +65 more
semanticscholar   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke: The EXTEND-IA TNK Part 2 Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance Intravenous thrombolysis with tenecteplase improves reperfusion prior to endovascular thrombectomy for ischemic stroke compared with alteplase.
B. Campbell, P. Mitchell, L. Churilov, N. Yassi, T. Kleinig, R. Dowling, B. Yan, Steven Bush, V. Thijs, R. Scroop, M. Simpson, M. Brooks, H. Asadi, Teddy Y. Wu, D. Shah, T. Wijeratne, Henry Zhao, F. Alemseged, F. Ng, P. Bailey, H. Rice, L. de Villiers, H. Dewey, P. Choi, H. Brown, K. Redmond, D. Leggett, J. Fink, W. Collecutt, Thomas Kraemer, M. Krause, D. Cordato, D. Field, Henry Ma, Billy O’Brien, B. Clissold, F. Miteff, A. Clissold, G. Cloud, L. Bolitho, Luke Bonavia, Arup Bhattacharya, A. Wright, Abul Mamun, F. O'rourke, J. Worthington, A. Wong, C. Levi, C. Bladin, G. Sharma, P. Desmond, M. Parsons, G. Donnan, S. Davis   +53 more
semanticscholar   +1 more source

Basilar Artery Occlusion Stroke Managed With Tenecteplase Versus Alteplase Before Endovascular Treatment (BAO‐TNK)

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To compare the effectiveness and safety of tenecteplase (TNK) versus alteplase (TPA) in patients with basilar artery occlusion prior to endovascular treatment (EVT). Methods In this retrospective multicenter study (BAO‐TNK), we analyzed consecutive BAO patients from 14 U.S.
Rahul R. Karamchandani, Dylan N. Wolman, Tyler M. Bielinski, Nitin Goyal, Jeremy B. Rhoten, Mahesh V. Jayaraman, Christian T. Sidebottom, Bradley A. Gross, Alhamza R. Al‐Bayati, Mohamed F. Doheim, Matthew K. Tobin, Anoop Chinthala, Avi Gajjar, Justin Mascitelli, Matthew R. Webb, Jan‐Karl Burkhardt, Kyle W. Scott, Visish Srinivasan, Daniel Tonetti, Manisha Koneru, David J. Altschul, Dhrumhil Vaishnav, Sumeet Multani, Thana Theofanis, William J. Ares, Je Yeong Sone, Ramin Zand, Sasan Bahrami, Jiang Li, Gary Defilipp, Dale Strong, Radmehr Torabi, Krisztina Moldovan, Kelsey E. Kline, Clemens M. Schirmer, Raul G. Nogueira, Alexandra R. Paul, Bradley N. Bohnstedt, Philipp Hendrix   +38 more
wiley   +1 more source

Emerging Detection Techniques for Large Vessel Occlusion Stroke: A Scoping Review

Frontiers in Neurology, 2022
Background: Large vessel occlusion (LVO) is the obstruction of large, proximal cerebral arteries and can account for up to 46% of acute ischaemic strokes (AIS) when both the A2 and P2 segments are included (from the anterior and posterior cerebral ...
J. K. Nicholls, Jonathan Ince, J. Minhas, E. Chung   +3 more
semanticscholar   +1 more source

Identifying large vessel occlusion at first glance in telemedicine

Journal of Neurology, 2023
Abstract Background Telemedicine has rapidly emerged as an important tool in emergency neurology. In particular, reliable biomarkers of large vessel occlusions (LVOs) are critically necessary in order to identify the need for in-hospital mechanical thrombectomy (MT).
Nils Schröter, Antonia Weiller, Michel Rijntjes, Andreas Harloff, Horst Urbach, Juraj Kukolja, Jürgen Bardutzky, Cornelius Weiller, Lena-Alexandra Beume   +8 more
openaire   +3 more sources

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source

Mechanical thrombectomy for large vessel occlusion with large ischaemic core 

Advances in Clinical Neuroscience & Rehabilitation
Endovascular therapy in acute ischemic stroke with large vessel occlusion changed the landscape of stroke treatment. Early randomised trials largely focused on patients with small to moderate ischemic core defined as ASPECTS 6 or greater.
Thanh N. Nguyen, Anurag Sahoo, Mohamad Abdalkader, Xiaochuan Huo, Zhongrong Miao, Marc Fisher   +5 more
doaj   +1 more source

Preliminary experience with recanalization of large vessel occlusion due to underlying long-segment dissection using a standby microwire technique

Frontiers in Neurology, 2022
PurposeThis study aimed at investigating a novel standby microwire technique to facilitate revascularization of large vessel occlusion due to underlying long-segment dissection.MethodsPatients with acute ischemic stroke with emergent large vessel ...
Xiaoxi Zhang, Hongye Xu, Zhengzhe Feng, Weilong Hua, Hongjian Shen, Lei Zhang, Yongxin Zhang, Pengfei Xing, Pengfei Yang, Xiaolong Xu, Zifu Li   +10 more
doaj   +1 more source