Results 61 to 70 of about 7,344,995 (290)

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Use of Diffusion‐Weighted Imaging‐Alberta Stroke Program Early Computed Tomography Score (DWI‐ASPECTS) and Ischemic Core Volume to Determine the Malignant Profile in Acute Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Malignant profiles were identified by imaging profiles and unfavorable outcomes that have poor response to reperfusion therapy. Many trials have used this profile in their inclusion criteria including large‐vessel occlusion acute ischemic ...
Takeshi Yoshimoto, Manabu Inoue, Hiroshi Yamagami, Kyohei Fujita, Kanta Tanaka, Daisuke Ando, Kazutaka Sonoda, Naruhiko Kamogawa, Masatoshi Koga, Masafumi Ihara, Kazunori Toyoda   +10 more
doaj   +1 more source

Prediction of Large Vessel Occlusions in Acute Stroke [PDF]

, 2016
: Objectives: Endovascular treatment for acute ischemic stroke with a large vessel occlusion was recently shown to be effective. We aimed to develop a score capable of predicting large vessel occlusion eligible for endovascular treatment in the early ...
Arnold, Marcel, Michael Amiguet, Heldner, Mirjam R., Gralla, J., Cras, Patrick, Mattle, Heinrich P., Mattle, H.P., Amiguet, Michael, Gralla, Jan, Fischer, Urs, Faouzi, M., Vanacker, Peter, Faouzi, Mohamed, Urs Fischer, Fischer, U., Ntaios, G., Michel, Patrik, Peter Vanacker, Amiguet, M., Mohamed Faouzi, Heinrich P. Mattle, Mattle, Heinrich, Mirjam R. Heldner, Arnold, M., Heldner, M.R., Ntaios, George, George Ntaios, Vanacker, P., Heldner, Mirjam Rachel, Patrick Cras, Cras, P., Jan Gralla, Marcel Arnold, Patrik Michel, Michel, P.   +34 more
core   +2 more sources

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

What predicts large vessel occlusion in mild stroke patients?

BMC Neurology, 2023
Background and purpose Mild acute ischemic stroke (AIS) patients with large vessel occlusion (LVO) may benefit from thrombolysis or thrombectomy therapy. However, the predictors for LVO in mild AIS patients have not been extensively explored. We aimed to
Zhengzhao Lu, Yunyun Xiong, Kaixuan Yang, Hongqiu Gu, Chunmiao Duan, Xingquan Zhao, Xia Meng, Yongjun Wang   +7 more
doaj   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Head Down Position Before Endovascular Treatment for Large Vessel Occlusion: Clinical Trial Design

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Head down position (HDP) shows potential benefits in acute ischemic stroke. Although −20° HDP appears safe, feasible, and potentially beneficial in patients with large artery atherosclerosis without reperfusion therapy, its value before ...
Zhao‐Xia Fei, Ying‐Jie Dai, Xin‐Hong Wang, Hui‐Sheng Chen   +3 more
doaj   +1 more source

The utility of histopathologic characteristics of thrombi in large vessel occlusions

Neurology Clinical Practice, 2019
Consider reviewing the histopathology of retrieved thrombi from patients treated with mechanical thrombectomy. Histopathologic features of thrombi have the potential to provide a large array of information in the identification of stroke mechanism and subsequent treatment.
Mohamed, Ridha, Adel, Malek, Knarik, Arkun, Lester Y, Leung   +3 more
openaire   +3 more sources

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source