Results 81 to 90 of about 7,344,995 (290)

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Accuracy of FAST-ED for Assessment Large Vessel Occlusion of Acute Ischemic Stroke in Emergency Department [PDF]

Chatchanan Pornpanit,1 Punnaporn Loymai,1 Nattaphol Uransilp,2 Winchana Srivilaithon1 1Department of Emergency Medicine, Faculty of Medicine, Thammasat University, Khlong Luang, Pathum Thani Province, Thailand; 2Division of Neurology, Department of ...
Uransilp N, Srivilaithon W, Pornpanit C, Loymai P   +3 more
core  

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Impact of the RNF213 p.R4810K Variant on Endovascular Therapy for Large‐Vessel Occlusion Stroke

, 2022
Background We investigated the impact of the ring finger protein 213 p.R4810K variant, a founder variant for moyamoya disease in East Asians, on endovascular therapy outcomes in patients with acute anterior‐circulation large‐vessel occlusion stroke in ...
Koge, Junpei, Nakaoku, Yuriko, Satoshi Saito, Masafumi Ihara, Kamogawa, Naruhiko, Kanta Tanaka, Saito, Satoshi, Maruyama, Hirofumi, Yamaguchi, Eriko, Kazunori Toyoda, Kazuo Washida, Inoue, Manabu, Hirofumi Maruyama, Satow, Tetsu, Yuriko Nakaoku, Jong‐Won Chung, Tsuyoshi Ohta, Hiroharu Kataoka, Kataoka, Hiroharu, Takeshi Yoshimoto, Hattori, Yorito, Tetsu Satow, Hiroshi Yamagami, Shiozawa, Masayuki, Yorito Hattori, Masatoshi Koga, Ogata, Soshiro, Soshiro Ogata, Bang, Oh Young, Yamagami, Hiroshi, Junpei Koge, Ohta, Tsuyoshi, Masayuki Shiozawa, Tanaka, Kanta, Kunihiro Nishimura, Washida, Kazuo, Koga, Masatoshi, Manabu Inoue, Oh Young Bang, Nishimura, Kunihiro, Yoshimoto, Takeshi, Toyoda, Kazunori, Ihara, Masafumi, Naruhiko Kamogawa, Tetsuya Chiba, Eriko Yamaguchi, Kawakami, Daisuke, Daisuke Kawakami, Chung, Jong\u2010Won, Chiba, Tetsuya   +49 more
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Effect of Intravenous Tirofiban Versus Placebo on First‐Pass Successful Reperfusion in Endovascular Stroke Thrombectomy: Insights From the RESCUE BT Randomized Clinical Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background First‐pass successful reperfusion (FPSR), defined as a successful/complete reperfusion achieved after a single thrombectomy pass, is predictive of favorable outcome in patients with acute ischemic stroke with large‐vessel occlusion.
Junjie Yuan, Hanming Ge, Zhaojun Tao, Huijie An, Qin Han, Jeffrey L. Saver, Thanh N. Nguyen, Simin Zhou, An Mao, Yuelu Wu, Raul Gomes Nogueira, Yaxuan Sun, Shunfu Jiang, Liping Wei, Xinmin Fu, Yongjie Bai, Shunyu Yang, Wei Hu, Guling Zhang, Chengde Pan, Shuai Zhang, Lin Qiao, Qiong Chen, Hongfei Sang, Zhongming Qiu, Fengfu Wu, Mingze Chang, Zhongfan Ruan   +27 more
doaj   +1 more source

Safety and Efficacy of Tenecteplase in Older Patients with Large Vessel Occlusion: A Pooled Analysis of the EXTEND-IA TNK Trials

, 2022
Background and Objectives Detailed study of tenecteplase (TNK) in patients older than 80 years is limited. The objective of our study was to assess the safety and efficacy of TNK at 0.25 and 0.40 mg/kg doses in patients older than 80 years with large ...
Kleinig, TJ, Yan, B, Dewey, HM, Donnan, GA, Churilov, L, Thijs, V, Mitchell, PJ, Wu, TY, Shah, DG, Desmond, PM, Yogendrakumar, V, Ng, FC, Wijeratne, T, Yassi, N, Parsons, MW, et al.   +15 more
core   +1 more source

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

Advanced Science, EarlyView.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu   +7 more
wiley   +1 more source

Fasting Blood Glucose on Prognosis After Acute Large Vessel Occlusion Reperfusion- A Multi-Center Study Based on Propensity Score Matching [PDF]

Bin Luo,1,2,* Yi Xiang,3,* Yueming Pan,4,* Fanlei Meng,5 Juanjuan Zhang,6 Zhiguang Liu,7 Peixian Lin,8 Long Zhang,9 Yubo Wang,2 Hecheng Ren,2 Lin Ma,2 Ying Huang2 1Academy of Medical Engineering and Translational Medicine, Tianjin
Meng F, Ren H, Lin P, Liu Z, Pan Y, Ma L, Huang Y, Zhang J, Xiang Y, Zhang L, Wang Y, Luo B   +11 more
core  

Platelet-Rich Emboli in Cerebral Large Vessel Occlusion Are Associated With a Large Artery Atherosclerosis Source

, 2019
Full author list omitted for brevity. For the full list of authors, see article.Background and Purpose- Nearly 30% of large vessel occlusion acute ischemic stroke clots are from an unknown source.
Fitzgerald, Sean, Brinjikji, Waleed, Puri, Ajit S, Gounis, Matthew J, Chueh, Juyu   +4 more
core   +1 more source