Results 161 to 170 of about 33,794 (267)

Fibro‐Adipogenic Progenitors Regulate Orofacial Neuromuscular Junction Regeneration via Myostatin

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Orofacial and limb muscles differ in embryonic origin and regenerative capacity. Neuromuscular junction (NMJ) regeneration is critical for muscle restoration both histologically and functionally. The relative potential of orofacial and limb muscles to form postsynaptic apparatuses remains elusive.
Ruizhi Li   +7 more
wiley   +1 more source

Acetyl‐Phosphate Dependent Protein Acetylation in Neisseria gonorrhoeae

open access: yesMicrobiologyOpen, Volume 15, Issue 2, April 2026.
The role of acetyl‐phosphate‐dependent non‐enzymatic protein acetylation in Neisseria gonorrhoeae was investigated through the deletion of the phosphotransacetylase (pta) and the acetate kinase (ackA) genes, this led to a decrease and increase in protein acetylation, respectively.
Ernesto F. D. Parga   +6 more
wiley   +1 more source

Fibrinogen‐Like Protein 2 Modulates B Cell Mucosal Immunity by Suppressing Receptor for Activated C‐Kinase 1‐Mediated AKT Phosphorylation

open access: yesMedComm, Volume 7, Issue 4, April 2026.
In our study, B cells are activated with the assistance of Breg and Tfh cells, subsequently differentiating into IgA+ plasma cells. These plasma cells produce secretory IgA (sIgA) at mucosal surfaces to combat viral and parasitic infections. Mechanistically, Fgl2 directly binds to Rack1.
Jiang Chang   +10 more
wiley   +1 more source

The Glymphatic System and Meningeal Lymphatics: Current Understandings and Future Perspectives

open access: yesMedComm, Volume 7, Issue 4, April 2026.
Brain waste clearance relies on the anatomical and functional integration of the glymphatic system and meningeal lymphatic vessels. Cerebrospinal fluid influx into the brain parenchyma occurs along periarterial spaces, a process driven by polarized aquaporin‐4 (AQP4) water channels on astrocytic endfeet.
Hangzhe Sun   +8 more
wiley   +1 more source

Targeting Mitochondrial Stress Responses: Terbinafine and Miglustat as Novel Lifespan and Healthspan Modulators

open access: yesAging Cell, Volume 25, Issue 4, April 2026.
Terbinafine and miglustat are mitohormetic compounds that extend lifespan and healthspan. In C. elegans, these FDA‐approved drugs engage both ATFS‐1 and DAF‐16, highlighting a stress‐dependent coordination between mitochondrial and IIS pathways distinct from canonical IIS activation, relevant for healthy aging.
Amélia Lalou   +15 more
wiley   +1 more source

Teleost‐specific ictacalcins exhibit similar structural organization, cation‐dependent activation, and transcriptional regulation as human S100 proteins

open access: yesThe FEBS Journal, Volume 293, Issue 7, Page 2042-2066, April 2026.
Calcium‐binding S100 proteins are important mediators of inflammation in humans. Distant members of this family have been recently discovered in teleost fish but their resemblance to human proteins has not been explored yet. This study demonstrates that zebrafish‐specific S100i1 and S100i2 (ictacalcins) possess identical structural organization and ...
Liz Hernández   +13 more
wiley   +1 more source

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