Results 181 to 190 of about 2,517,606 (239)

Functional validation of driver mutation‐specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity

open access: yesThe Journal of Pathology, Volume 270, Issue 2, Page 226-240, October 2026.
Abstract Uveal melanoma (UM) is a deadly ocular malignancy with well‐described genetic alterations that predict disease outcome. However, our current understanding of the biological underpinnings of high‐risk uveal melanoma progression remains relatively limited. Using RNA expression profiles from 250 patients with UM, we identified 12 novel biomarkers
QCC van den Bosch   +7 more
wiley   +1 more source

Green Synthesis of Gold Nanoparticles Using Hibiscus: Antioxidant, Anticancer and Toxicity Evaluation in Biological Models

open access: yesParticle &Particle Systems Characterization, Volume 43, Issue 10, October 2026.
Green synthesis of gold nanoparticles using Hibiscus plant and its biological evaluation such as antioxidant, anticancer and toxicity evaluation using in vitro and in vivo models. ABSTRACT Gold nanoparticles (GNPs) are metallic structures that have been widely studied owing to their outstanding physicochemical properties it can be implemented for ...
Ravichandran Manisekaran   +6 more
wiley   +1 more source

A bacterial protein inhibitor of dUTPase disrupts zebrafish embryogenesis through a conserved active‐site mechanism

open access: yesProtein Science, Volume 35, Issue 10, October 2026.
Abstract Deoxyuridine triphosphatase (dUTPase) is essential for DNA replication fidelity and embryonic development in metazoa, yet whether a protein inhibitor can acutely disrupt dUTPase function in a living vertebrate has not been tested. The Staphylococcus aureus Stl protein inhibits diverse dUTPases in vitro, but its efficacy in a eukaryotic ...
Viktória Perey‐Simon   +7 more
wiley   +1 more source

Implementation of the In Vitro Seizure Liability Assay (iLAseizure) in Drug Discovery and Development: Mechanism of Action Case Studies

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Central nervous system (CNS) liabilities remain a significant cause of attrition during small molecule drug development. We previously developed the in vitro seizure liability assay (iLAseizure), a new approach methodology (NAM) comprising a human induced pluripotent stem cell neuron microelectrode array (MEA) assay coupled with a panel of ...
Kimberly Rockley   +5 more
wiley   +1 more source

Exploring Interactive Effects of Arsenic and Selenium Exposure on Larval Zebrafish (Danio rerio)

open access: yesEnvironmental Toxicology, Volume 41, Issue 10, Page 1027-1040, October 2026.
ABSTRACT Arsenic contamination in aquatic ecosystems is a major environmental concern. Selenium (Se) helps mitigate oxidative stress and hence could reduce the toxic effects of arsenic. However, Se can also be toxic at high concentrations. Given that these metalloids commonly co‐occur in the environment, there is a pressing need for further research ...
Owen Luo   +6 more
wiley   +1 more source

Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies

open access: yesAging Cell, Volume 25, Issue 10, October 2026.
AMP‐activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated in metabolic health and disease, as well as in ageing. Here, we show that direct pharmacological activation of AMPK with the compound 991 in vivo extends lifespan in multiple model organisms: the fission yeast Schizosaccharomyces ...
Eliano dos Santos   +15 more
wiley   +1 more source

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