Results 181 to 190 of about 2,517,606 (239)
Abstract Uveal melanoma (UM) is a deadly ocular malignancy with well‐described genetic alterations that predict disease outcome. However, our current understanding of the biological underpinnings of high‐risk uveal melanoma progression remains relatively limited. Using RNA expression profiles from 250 patients with UM, we identified 12 novel biomarkers
QCC van den Bosch +7 more
wiley +1 more source
Green synthesis of gold nanoparticles using Hibiscus plant and its biological evaluation such as antioxidant, anticancer and toxicity evaluation using in vitro and in vivo models. ABSTRACT Gold nanoparticles (GNPs) are metallic structures that have been widely studied owing to their outstanding physicochemical properties it can be implemented for ...
Ravichandran Manisekaran +6 more
wiley +1 more source
Bacteriophage therapy against American foulbrood in honey bees: a PRISMA-guided systematic review. [PDF]
Walter N +4 more
europepmc +1 more source
Abstract Deoxyuridine triphosphatase (dUTPase) is essential for DNA replication fidelity and embryonic development in metazoa, yet whether a protein inhibitor can acutely disrupt dUTPase function in a living vertebrate has not been tested. The Staphylococcus aureus Stl protein inhibits diverse dUTPases in vitro, but its efficacy in a eukaryotic ...
Viktória Perey‐Simon +7 more
wiley +1 more source
Nasal Myiasis Associated With <i>E. coli</i> Bacteremia, Spinal Osteomyelitis, and Epidural Abscess: A Case Report. [PDF]
Miller F, McLean J, DiDiodato G.
europepmc +1 more source
ABSTRACT Central nervous system (CNS) liabilities remain a significant cause of attrition during small molecule drug development. We previously developed the in vitro seizure liability assay (iLAseizure), a new approach methodology (NAM) comprising a human induced pluripotent stem cell neuron microelectrode array (MEA) assay coupled with a panel of ...
Kimberly Rockley +5 more
wiley +1 more source
The use of Galleria mellonella to study microbial interactions, immune responses, and substrate interactions. [PDF]
Maslova E, Staber C, McCarthy RR.
europepmc +1 more source
Exploring Interactive Effects of Arsenic and Selenium Exposure on Larval Zebrafish (Danio rerio)
ABSTRACT Arsenic contamination in aquatic ecosystems is a major environmental concern. Selenium (Se) helps mitigate oxidative stress and hence could reduce the toxic effects of arsenic. However, Se can also be toxic at high concentrations. Given that these metalloids commonly co‐occur in the environment, there is a pressing need for further research ...
Owen Luo +6 more
wiley +1 more source
Molecular identification of Hypoderma sinense cutaneous myiasis in a child from a cattle-raising pastoral region of China: a case report. [PDF]
Ji Q, He S, Lai S, Long S, Jing X, Lu Y.
europepmc +1 more source
Direct Pharmacological Activation of AMPK Extends Lifespan in Yeast, Worms and Flies
AMP‐activated protein kinase (AMPK) is a key evolutionarily conserved sensor of energy homeostasis, which is implicated in metabolic health and disease, as well as in ageing. Here, we show that direct pharmacological activation of AMPK with the compound 991 in vivo extends lifespan in multiple model organisms: the fission yeast Schizosaccharomyces ...
Eliano dos Santos +15 more
wiley +1 more source

