Results 161 to 170 of about 13,747 (240)

Virtual Screening and Zebrafish Phenotype‐Based Evaluation Argues Against Repurposing 4‐Phenylbutyrate for STXBP1‐Related Disorders

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Syntaxin‐binding protein 1 (STXBP1) mutations lead to severe epilepsy, intellectual disability, developmental delay, and movement disorder. Effective treatments for these conditions do not exist. Recent studies in Munc18‐1 (STXBP1) C. elegans models demonstrate that 4‐phenylbutyrate (4‐PBA) or related pharmacological chaperones stabilize ...
Aline Frick, Paige Whyte‐Fagundes, Scott C. Baraban   +2 more
wiley   +1 more source

Isolation of a Novel Lytic Pseudomonas aeruginosa Phage Henu5 and Fitness Costs of Phage‐Driven Resistance

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
This study isolated and identified a novel lytic phage that infects Pseudomonas aeruginosa. Henu5 exhibited good physicochemical stability. Additionally, the phage‐resistant mutants showed fitness trade‐offs in growth, virulence and antibiotic susceptibility, along with in vivo fitness, which might direct future phage selection in clinical settings ...
Salwa E. Gomaa, Jiawen Shen, Jingjing Li, Yangyang Liu, Chaonan Ma, Qiming Li, Guanbin Qi, Tieshan Teng   +7 more
wiley   +1 more source

Current issues in heartworm chemotherapy. [PDF]

Parasit Vectors
Geary TG.
europepmc   +1 more source

Atypical Tetracyclines Promote Longevity and Ferroptotic Neuroprotection via Translation Attenuation

Aging Cell, Volume 25, Issue 6, June 2026.
Tetracyclines extend lifespan and protect neurons from ferroptosis by attenuating protein synthesis across multiple eukaryotic models through ISR‐dependent or ISR‐independent mechanisms, enabling classification based on their mode of action. ABSTRACT Reducing protein synthesis extends lifespan across taxa, but pharmacological strategies to safely ...
Khalyd J. Clay, Manuel Sanchez‐Alavez, Ian Newman, Na Na, Ana P. Verduzco Espinoza, Alan To, Shannon Saad, Hollis T. Cline, Michael Petrascheck   +8 more
wiley   +1 more source

Salvianolic acid B synergizes with azoles against <i>Candida glabrata</i> cells in vulvovaginal candidiasis. [PDF]

Front Cell Infect Microbiol
Chen Y, Zhang Y, Lu L, Wang Q, Gao J, Ying C.   +5 more
europepmc   +1 more source

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

Cell Proliferation, Volume 59, Issue 6, June 2026.
The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao, Yuqing Sun, Yutao Huang, Qinghang Meng, Xinhua Lin, Wei Wei, Xiaofang Tang   +6 more
wiley   +1 more source

Bioluminescent <i>Mycobacterium abscessus</i> in <i>Galleria mellonella</i>: a preclinical screening tool for antimycobacterial compounds. [PDF]

Front Cell Infect Microbiol
Van Win T, Brangers W, Reséndiz Sharpe A, Wijnant GJ, André E, Vande Velde G.   +5 more
europepmc   +1 more source

Cucumber‐Derived Exosome‐Like Vesicles With Melanin‐Inhibitory Activity and an Acceptable in Vitro Safety Profile

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Skin hyperpigmentation disorders affect millions worldwide, driving demand for depigmentation products. However, many conventional skin‐lightening products contain dangerous ingredients, including mercury and unregulated hydroquinone.
Che‐Yuan Hsu, Wei‐Chen Chen, Horng‐Shen Chen, Yu‐Chen Liao, Cheng‐Han Hsieh, Donald Liu, Ya‐Wen Cheng   +6 more
wiley   +1 more source

Proliferative sparganosis caused by <i>Spirometra</i> sp. 3 in a dog. [PDF]

J Vet Diagn Invest
Miller LR, Harley SK, Pollock IL, Amerman HK, Sobotyk C.   +4 more
europepmc   +1 more source

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

Molecular Microbiology, Volume 125, Issue 6, Page 506-545, June 2026.
Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall‐targeting antimicrobials, combining RNAseq and high‐resolution tiling arrays. We revealed the complexity of the CESR, the contribution of extracytoplasmic function sigma factors (ECFs) and two‐component signal transduction ...
Qian Zhang, Charlène Cornilleau, Lena Friebel, Sarah Spitzner, Raphael R. Müller, Doreen Meier, Pierre Flores, Cyprien Guérin, Pierre Nicolas, Diana Wolf, Vincent Fromion, Rut Carballido‐López, Thorsten Mascher   +12 more
wiley   +1 more source