In this study, a rational in silico strategy was employed to design a bioinsecticidal peptide targeting the digestive trypsins of Spodoptera frugiperda, utilizing the Dioscorin–trypsin interface as a structural template. By identifying critical interface hot‐spot residues, an 11‐residue oligopeptide designated as PEP‐11 was engineered, demonstrating ...
José Severiche‐Castro +2 more
wiley +1 more source
Beyond Eosinophilia: A Multisystem, Non-eosinophilic Löffler-Like Pulmonary Syndrome From Household Helminthic Transmission. [PDF]
Memari K +5 more
europepmc +1 more source
Cedrela fissilis Vell. Inner Bark: LC–MS/MS‐Based Chemical Profiling and Toxicological Effects
ABSTRACT Investigating the mechanistic toxicity of plant extracts is essential for safety assessment. The predictive toxicological effects of Cedrela fissilis were evaluated, and LC–MS/MS‐based chemical profiling was performed. The hydroethanolic extract (HeECf) and ethyl acetate (EA) fraction were assessed in multimodel systems with different levels ...
Thainá Pereira da Silva Cabral +10 more
wiley +1 more source
Antibacterial and antioxidant potentials of larval extract of black soldier fly, <i>Hermetia illucens</i> and blow fly, <i>Lucilia sericata</i>, for biomedical applications. [PDF]
Marzan SM +5 more
europepmc +1 more source
Hydatid Cyst of the Thyroid Gland With Concurrent Hepatic Involvement: A Rare Case Report
ABSTRACT Hydatidosis, caused by Echinococcus granulosus, most commonly affects the liver and lungs, while thyroid involvement is exceptionally rare and can mimic other cystic thyroid lesions. We report a 40‐year‐old woman with no history of animal exposure who presented with anterior neck swelling, odynophagia, and abdominal discomfort. She had a prior
Hana Saffar, Aysan Nozheh, Maral Edalati
wiley +1 more source
All the bedroom's a stage: Reconceptualizing sex as “performance” to sex as “rehearsal”
Abstract In the United States, sex is often spoken about in terms of performance, and naturally invokes language of theatricality. Sexual performance has been used as an umbrella term to refer to sexual satisfaction, behavior, embodiment, and also pathology in terms of conditions such as erectile dysfunction.
Taylor Harmon
wiley +1 more source
Albendazole-doxycycline combination therapy alleviates MRI- and pathology-evident neuroinflammation and restores IL-33/GFAP balance in mouse neuroangiostrongyliasis. [PDF]
Jhan KY +9 more
europepmc +1 more source
Tet regulates lipid metabolism and cell apoptosis to alleviate NAFLD. Integrated network pharmacology, Mendelian randomization, and experimental validation demonstrate that Tet activates the PI3K/AKT/STAT3 signaling axis, suppresses apoptosis, reduces hepatic lipid accumulation, and improves biochemical liver injury markers, supporting its potential as
Peng Sun +11 more
wiley +1 more source
Candidozyma auris-infected Galleria mellonella larvae: the effect of the humanized monoclonal antibody Dia-T51 and its synergy with amphotericin B. [PDF]
Vanzolini T, Fiori V, Magnani M.
europepmc +1 more source
Food‐grade processing of Pastinaca sativa (parsnip) converts a nutrient‐rich plant matrix (dietary fiber, fructans, phenolics) through washing/slicing/enzymatic treatment and ingredient preparation into functional food ingredients, including fiber concentrates, antioxidant‐rich fractions, and parsnip powders/extracts.
Somanjana Khatua +7 more
wiley +1 more source

