Results 71 to 80 of about 33,794 (267)
Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death [PDF]
, 2018 The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches.
Cordero, Julia B. +2 more
core +3 more sources
Advanced Science, EarlyView.Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su +4 more
wiley +1 more source
Effects of Lucilia sericata Larval Secretion on Echinococcus granulosus
Türkiye Parazitoloji DergisiObjective: Echinococcus granulosus causes echinococcosis when its larvae settle in various organs, especially the liver and lung, of humans and herbivorous animals such as sheep and cattle.
Feza İrem Aldı +3 more
doaj +1 more source
Advanced Science, EarlyView.Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan +11 more
wiley +1 more source
High-Dose Ionizing Radiation Impairs Healthy Dendrite Growth in C. elegans
Advances in Radiation OncologyPurpose: The nervous system is vulnerable to radiation damage, and further optimization is required to increase the efficacy of radiation therapy while reducing harm to neurons. Given recent developments in heavy ion therapy, experimental models would be
Robert Freitag, BA +5 more
doaj +1 more source
Animals, 2020 The culture of red cusk eel Genypterus chilensis is currently considered a priority for Chilean aquaculture but low larval survival rates have prompted the need for the continuous use of antibacterials. The main aim of this study was to evaluate the role
Luz Hurtado +5 more
doaj +1 more source
Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases
Animal Models and Experimental Medicine, EarlyView.Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam +4 more
wiley +1 more source
Debridement of wounds with honey [PDF]
, 2009 Honey has been used as a debriding agent since ancient times. Its debriding properties have been rediscovered in more recent times, with various case reports published in the latter decades of the 20th century describing its effectiveness in cleaning up ...
Molan, Peter C.
core +1 more source
Why use of interventions targeting outdoor biting mosquitoes will be necessary to achieve malaria elimination [PDF]
, 2012 By definition, elimination of malaria means permanent reduction to zero of locally incidence of infections. Achieving this goal among other reasons, it requires fully understanding on where and when persons are most exposed to malaria vectors as these ...
Ferguson, H., Govella, N.J.
core +4 more sources
Real‐time biosensing of Parkinson's disease biomarkers via NIR‐activated upconversion nanoparticles
BMEMat, EarlyView.Schematic illustration of the luminescence resonance energy transfer‐driven core‐shell‐shell UCNPs (cssUCNPs@Fluo4) nanoprobe for simultaneous monitoring of Ca²⁺‐temperature dynamics in Parkinson's disease models. Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with incompletely understood pathophysiology, necessitating ...
Jialin Liu +9 more
wiley +1 more source