Results 31 to 40 of about 3,057,389 (302)

RETRACTED: Tanshinone sensitized the antitumor effects of irradiation on laryngeal cancer via JNK pathway

open access: yesCancer Medicine, 2018
Laryngeal cancer is a common cancer occurred in the head and neck. Irradiation sensitivity is a problem affecting the treatment of laryngeal cancer. Tanshinone IIA has been reported to play an important role in treating multiple diseases; yet, whether ...
Hui Xu   +4 more
doaj   +1 more source

Changes in metabolic syndrome status and risk of laryngeal cancer: A nationwide cohort study.

open access: yesPLoS ONE, 2021
BackgroundWhether dynamic changes of metabolic syndrome (MetS) affects the subsequent laryngeal cancer occurrence remains unknown.ObjectiveThis study investigated the effects of changes of MetS on the incidence of laryngeal cancer due to a lack of ...
Hyun-Bum Kim   +3 more
doaj   +1 more source

Isolated Laryngeal Amyloidosis Mimicking Laryngeal Cancer [PDF]

open access: yesCureus, 2018
Amyloidosis is the deposition of an extracellular fibrillar protein in the tissues leading to organ dysfunction. Laryngeal amyloidosis is a rare phenomenon. We report a case of isolated laryngeal amyloidosis which was initially suspicious for laryngeal cancer on magnetic resonance imaging (MRI) but histopathology showed the presence of amyloid ...
Muneeb, Aeman, Gupta,, Supriya
openaire   +2 more sources

Incidence and survival in laryngeal and lung cancers in Finland and Sweden through a half century.

open access: yesPLoS ONE, 2022
Global survival studies have shown favorable development in most cancers but few studies have considered laryngeal cancer, particularly over extended periods or in populations for which medical care is essentially free of charge.
Anni Koskinen   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Upregulation of MiR-196a promotes cell proliferation by downregulating p27kip1 in laryngeal cancer

open access: yesBiological Research
BACKGROUND: Accumulating evidence has confirmed that miR-196a plays a critical role in tumorigenesis and tumor progression in a variety of cancers. It has been demonstrated that miR-196a is highly up-regulated in laryngeal cancer by miRNA profiling ...
Jin Cheng, Zhang Yi, Li Jiping
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Comprehensive analysis of the immune implication of EPHX4 gene in laryngeal squamous cell carcinoma

open access: yesBrazilian Journal of Otorhinolaryngology
Objectives: The role of Epoxide Hydrolase-4 (EPHX4), a member of epoxide hydrolase family, has not been investigated in cancer. The purpose of this article is to explore the application value of EPHX4 in laryngeal cancer and its relationship with immune ...
Nimei Shen   +6 more
doaj   +1 more source

Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade

open access: yesJournal of International Medical Research, 2022
Objective To detect the expression of fibrinogen like protein-1 (FGL-1) in laryngeal cancer and evaluate its effect on tumor proliferation, metastasis, and antitumor immunity.
Jiameng Huang   +6 more
doaj   +1 more source

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