Results 41 to 50 of about 3,057,389 (302)

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Development and Validation of an Immune-Related Signature for the Prediction of Recurrence Risk of Patients With Laryngeal Cancer

Frontiers in Oncology, 2021
ObjectiveOur purpose was to develop and verify an immune-related signature for predicting recurrence risk of patients with laryngeal cancer.MethodsRNA-seq data of 51 recurrence and 81 non-recurrence laryngeal cancer samples were downloaded from TCGA ...
Hang Zhang, Xudong Zhao, Jin Wang, Wenyue Ji   +3 more
doaj   +1 more source

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

The primary growth of laryngeal squamous cell carcinoma cells in vitro is effectively supported by paired cancer-associated fibroblasts alone

Tumor Biology, 2017
Most primarily cultured laryngeal squamous cell carcinoma cells are difficult to propagate in vitro and have a low survival rate. However, in our previous work to establish a laryngeal squamous cell carcinoma cell line, we found that laryngeal cancer ...
Mei Wang, Chunping Wu, Yu Guo, Xiaojuan Cao, Wenwei Zheng, Guo-Kang Fan   +5 more
doaj   +1 more source

Association of gastroesophageal reflux disease and laryngeal cancer

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2018
Objective: Studies examining the association of reflux disease with the risk of developing laryngeal cancer have both proven and disproven the null hypothesis.
Mursalin M. Anis, Mir-Muhammad Razavi, Xiao Xiao, Ahmed M.S. Soliman   +3 more
doaj   +1 more source

Synchronous laryngeal cancer

Romanian Journal of Morphology and Embryology
Multiple primary cancers are usually defined as primary malignant tumors of different histological origins in one person. Synchronous cancers are defined as two or more primary cancers diagnosed in the same patient at the same time or within six months after identifying the first tumor, and those cancers that develop at more than a six-month interval ...
Ciolofan, Mircea Sorin, Anghelina, Florin, Vlăescu, Alexandru Nicolae, Mitroi, Mihaela Roxana, Căpitănescu, Alina Nicoleta, Ioniţă, Elena, Ioniţă, Iulică, Ionovici, Nina, Vrînceanu, Daniela, Mogoantă, Carmen Aurelia   +9 more
openaire   +2 more sources

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

ASSESSMENT OF EXTRACELLULAR AND INTRACELLULAR PROTEOLYSIS IN PRETUMOR AND TUMOR DISEASES OF THE LARYNX

Сибирский онкологический журнал, 2016
The expression of matrix metalloproteinase (MMP) genes and activity of proteasomes and calpains were studied in patients with precancerous laryngeal lesions and laryngeal cancer.
I. V. Kondakova, G. V. Kakurina, L. V. Spirina, О. V. Cheremisina, О. V. Pankova, К. Yu. Menshikov   +5 more
doaj  

Identification of prognostic immune genes in laryngeal cancer

Journal of International Medical Research, 2020
Objective In this study, we aimed to identify prognostic immune-related genes and establish a prognostic model for laryngeal cancer based on these genes.
Huan Xiao, Qi-sheng Su, Chao-qian Li
doaj   +1 more source

Childhood, adolescent and young adult cancer: cancer trends report

, 2023
This is the third Cancer Trends Report the National Cancer Registry Ireland (NCRI) has published on childhood cancers and the first to include cancers in adolescents and young adults (AYA) (up to 24 years of age).
National Cancer Registry Ireland (NCRI)
core