Results 21 to 30 of about 6,231 (229)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Laser-driven composite ceramic enabling superhigh-luminance white light

Journal of Materiomics
Laser-remote activated phosphor (LARP) converted solid state lighting is now developing towards high power density and super-brightness, and phosphor ceramic converters with high efficiency, high thermal conductivity, acceptable transmittance and ...
Rundong Tian, Tianliang Zhou, Rong-Jun Xie   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Origins of heat and luminous saturation in LuAG:Ce thin films for high-power laser lighting

Journal of Advanced Ceramics
The performance of high-power laser-driven lighting systems is fundamentally limited by an insufficient understanding of the mechanisms governing heat generation and luminous saturation in color-converting materials.
Bingguo Xue, Shaohong Liu, Huiying Hu, Limin Zhou, Hao Cui, Hongying Pei, Wenyan Zhou, Manmen Liu, Haigang Dong, Ming Wen, Li Chen, Wei Wang, Song Li, Liang Zuo   +13 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Ce:GAGG and Al2O3−Ce:GAGG phosphor ceramics for laser-driven lighting: Effects of Ga3+ substitution

Journal of Advanced Ceramics
Monophase Ce:Gd3Al5−xGaxO12 (Ce:GAGG) with x = 0.5–3.0 and 50 vol% Al2O3−containing composite phosphor ceramics (PCs) were prepared in a pure oxygen atmosphere.
Denis Yu. Kosyanov, Anastasia A. Vornovskikh, Alexey P. Zavjalov, Zlata E. Priimak, Andrei A. Leonov, Andrei A. Obraztsov, Yanbin Wang, Ziqiu Chen, Zhenzhen Zhou, Jiang Li   +9 more
doaj   +1 more source

A New Line for Laser-Driven Light Ions Acceleration and Related TNSA Studies [PDF]

Applied Sciences, 2017
In this paper, we present the status of the line for laser-driven light ions acceleration (L3IA) currently under implementation at the Intense Laser Irradiation Laboratory (ILIL), and we provide an overview of the pilot experimental activity on laser-driven ion acceleration carried out in support of the design of the line.
Gizzi Leonida Antonio, Giove Dario, Altana Carmen, Brandi Fernando, Cirrone Pablo, Cristoforetti Gabriele, Fazzi Alberto, Ferrara Paolo, Fulgentini Lorenzo, Koester Petra, Labate Luca, Lanzalone Gaetano, Londrillo Pasquale, Mascali David, Muoio Annamaria, Palla Daniele, Schillaci Francesco, Sinigardi Stefano, Tudisco Salvatore, Turchetti Giorgio   +19 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light [PDF]

ACS Central Science, 2018
Visible light-promoted organic reactions can offer increased reactivity and selectivity via unique reaction pathways to address a multitude of practical synthetic problems, yet few practical solutions exist to employ these reactions for multi-kilogram production.
Kaid Harper, Eric Moschetta, shailendra Bordawekar, steven wittenberger   +3 more
openaire   +4 more sources