Results 61 to 70 of about 114,505 (312)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Laser transfer of sol-gel ferroelectric thin films using an ITO release layer [PDF]

, 2011
A new laser transfer process is reported which allows damage-free transfer of ferroelectric thin films from a growth substrate directly to a target substrate.
Bansal, A., D. Bhattacharyya, Yeatman, E. M., A. Bansal, R.V. Wright, Bhattacharyya, Debabrata, P.B. Kirby, G. Dou, Dou, G., A.S. Holmes, Hergert, R., E.M. Yeatman, R. Hergert, Holmes, A. S., Wright, Robert V., Kirby, Paul B.   +15 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Rapid and mask-less laser-processing technique for the fabrication of microstructures in polydimethylsiloxane

, 2014
We report a rapid laser-based method for structuring polydimethylsiloxane (PDMS) on the micron-scale. This mask-less method uses a digital multi-mirror device as a spatial light modulator to produce a given spatial intensity pattern to create arbitrarily
Sones, C.L., Mills, B., Butement, J., Feinäugle, M., Mosayyebi, Ali, Katis, I.N., Eason, R.W.   +6 more
core   +1 more source

Analysis of the Laser Ablation Threshold of Aluminum Foil under Varying Relative Humidity Conditions [PDF]

한국정밀공학회지
To reduce the use of fossil fuels, the adoption of battery electric vehicles (BEVs) using lithium-ion batteries has been increasing in internal combustion engine alternatives.
Myeongho Park, Dongkyoung Lee
doaj   +1 more source

Production Micro and Nano magnesium powder by Pulsed Laser Ablation [PDF]

Engineering and Technology Journal, 2017
In this work, magnesium oxide micro/nano particles were prepared using laser ablation in deionized water. This is technique very simple, cheap and a single step method. In the present work, at which ablation of pure Mg metal target in deionized water was
Z.A. Khaleefah, A.Z. Mohammed, M.S. Hamza   +2 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Mixing enthalpy-driven variations in ablation thresholds and laser-induced crater morphologies of CoCuFeNiMnMox (x=0.5, 1.0, 1.5) high-entropy alloys under UV nanosecond laser pulses

Results in Surfaces and Interfaces
This study investigates the ablation threshold fluence and power dependence of ablation process in CoCuFeNiMnMox (x = 0.5, 1.0, and 1.5) high-entropy alloys under ultraviolet nanosecond laser pulses.
Hossein Mahdavi, Abdullah Kepçeoğlu, Armin Asghari Alamdari, Uğur Ünal, Hadi Jahangiri   +4 more
doaj   +1 more source