Results 41 to 50 of about 74,366 (263)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Global trends of laser bone ablation: bibliometric analysis of publications from 1979 to 2023

Frontiers in Surgery
ObjectivesThe objective of the bibliometric analysis was to quantify and identify the current status and trends of laser bone ablation research from 1979 to 2023.Materials and methodsThe Web of Science (WOS) core collection database was used to search ...
Kai-Jun Zhang, Qi Liu, Qi Liu, Teng Zhang, Anjie Shen, Wei Han, Wei Han, Jinqi Li, Bin Zhao, Bin Zhao, Junqiang Wang, Junqiang Wang, Junqiang Wang   +12 more
doaj   +1 more source

Effect of laser energy and ablation time on the formation of aluminum nanoparticles by nanosecond laser ablation of aluminum target in ethanol

Iraqi Journal of Physics, 2019
In this work we study the influence of the laser pulse energy and ablation time on the aluminum nanoparticles productivity during nanosecond laser ablation of bulk aluminum immersed in liquid.
Kadhim A. Aadim
doaj   +1 more source

Theoretical fundamentals of short pulse laser–metal interaction: A review

Nanotechnology and Precision Engineering, 2020
Short and ultrashort pulse lasers offer excellent advantages in laser precision machining mainly because of their high pulse energy and low ablation threshold.
Xinxin Li, Yingchun Guan
doaj   +1 more source

Enhancement of ablation and ultrafast electron dynamics observation of nickel-based superalloy under double-pulse ultrashort laser irradiation

Journal of Materials Research and Technology, 2022
Temporally shaped femtosecond laser machining is a flexible and effective method to improve the efficiency and quality of cooling film holes. This study investigated the ablation of nickel-based superalloy by double-pulse femtosecond laser with different
Zhicheng Chen, Lan Jiang, Yiling Lian, Kaihu Zhang, Zenan Yang, Jingya Sun   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Production Micro and Nano magnesium powder by Pulsed Laser Ablation [PDF]

Engineering and Technology Journal, 2017
In this work, magnesium oxide micro/nano particles were prepared using laser ablation in deionized water. This is technique very simple, cheap and a single step method. In the present work, at which ablation of pure Mg metal target in deionized water was
Z.A. Khaleefah, A.Z. Mohammed, M.S. Hamza   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source