Results 51 to 60 of about 2,528,330 (341)

Feasibility investigation of direct laser cutting process of metal foam with high pore density [PDF]

, 2018
To avoid damage to the pore structure of metal foam, a laser cutting process for efficiently and directly cutting metal foam into regular shapes is proposed.
AC Kaya, B Zhang, C Cai, CC Shen, CY Zhao, ER Raj, G Castro, GL Han, H Jin, H Yu, HAL Adrian, I Aartun, J Banhart, J Muth, K Ji, Kwan San Hui, L Giani, M Billiet, M Lacroix, M Wang, MF Scott, MM Alexander, Q Tian, R Zou, S Nisar, S Ozan, S Peirovi, Shaoyu Liu, W Ke, W Zhou, W Zhou, Wei Zhou, X Li, X Lin, Xuyang Chu, Yangxu Liu, YJ Kwon, Z Song   +37 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Possible explanations for different surface quality in laser cutting with 1 micron and 10 microns beams [PDF]

, 2012
In laser　cutting　of　thick　steel　sheets,　quality　difference　is　observed　between　cut　surfaces　obtained　with 1 micron and 10 micron laser beams. This paper investigates physical mechanisms for this interesting and important problem of the wavelength ...
Golubev V. S., Grigory E., Hilton P. A., Himmer T., Koji Hirano, Petring D., Remy Fabbro, Scintilla L. D., Scintilla L. D., Vossen G., Wandera C.   +10 more
core   +6 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

SOFTWARE TOOL FOR LASER CUTTING PROCESS CONTROL – SOLVING REAL INDUSTRIAL CASE STUDIES

Facta Universitatis. Series: Mechanical Engineering, 2016
Laser cutting is one of the leading non-conventional machining technologies with a wide spectrum of application in modern industry. It order to exploit a number of advantages that this technology offers for contour cutting of materials, it is necessary ...
Miloš Madić, Marko Kovačević, Miroslav Radovanović, Vladislav Blagojević   +3 more
doaj   +1 more source

Improving of the wear resistance of working parts agricultural machinery by the implementation of the effect of self-sharpening [PDF]

, 2016
The failure of the cutting elements of farm machinery is due to the blunting of cutting edges (increase of their radius) till the limit values. The most effective method for increasing the wear resistance of farm machinery is the realization of self ...
Arifa, W., Aulin, V., Kuzyk, A., Lysenko, S., Аулін, В. В., Кузик, О. В., Лисенко, С. В.   +6 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Performance of laser assisted micro-milling (laμmill) of titanium alloy using micro ball end mill [PDF]

, 2018
Laser assisted milling technique turns to be complicated and unpredictable when the machining size is scaled to micro level. Furthermore, less has been reported on the application of ball end mill in laser assisted micro milling.
Mohid, Zazuli
core