Results 71 to 80 of about 21,821,173 (350)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Bulk-Explosion-Induced Metal Spattering During Laser Processing

Physical Review X, 2019
High-resolution x-ray imaging of a laser-based manufacturing technique has captured the formation process of molten metal projectiles that produce imperfections.
Cang Zhao, Qilin Guo, Xuxiao Li, N. Parab, K. Fezzaa, W. Tan, Lianyi Chen, T. Sun   +7 more
semanticscholar   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Monitoring of temperature profiles and surface morphologies during laser sintering of alumina ceramics

Journal of Asian Ceramic Societies, 2014
Additive manufacturing of alumina by laser is a delicate process and small changes of processing parameters might cause less controlled and understood consequences.
Bin Qian, Lauri Taimisto, Antti Lehti, Heidi Piili, Olli Nyrhilä, Antti Salminen, Zhijian Shen   +6 more
doaj   +1 more source

Compensation for time fluctuations of phase modulation in a liquid-crystal-on-silicon display by process synchronization in laser materials processing [PDF]

, 2011
We demonstrate the adverse influence of temporal fluctuations of the phase modulation of a spatial light modulator (SLM) display device on nanosecond laser micromachining.
Beck, Rainer J, Hand, Duncan P., Parry, Jonathan P., Shephard, Jonathan D.   +3 more
core   +1 more source

The influence of laser processing parameters on the densification and surface morphology of pure Fe and Fe-35Mn scaffolds produced by selective laser melting

Journal of Manufacturing Processes, 2019
Highly customisable implants with lattice structures can be achieved using selective laser melting (SLM) paving the way for tailored biodegradable Fe-based implants.
D. Carluccio, A. Demir, L. Caprio, B. Previtali, M. Bermingham, M. Dargusch   +5 more
semanticscholar   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

An overview of laser surface modification of die steels [PDF]

, 2008
In recent years, surface modification using advanced heat source like laser has been replacing the conventional methods to produce amorphous microstructure via rapid solidification.
Aqida, S.N., Brabazon, Dermot, Maurel, M., Naher, Sumsun   +3 more
core  

A two-stage ceramic tile grout sealing process using a high power diode laser Part I: Grout development and materials characteristics [PDF]

, 1998
Work has been conducted using a 60 W-cw high power diode laser (HPDL) in order to determine the feasibility and characteristics of sealing the void between adjoining ceramic tiles with a specially developed grout material having an impermeable enamel ...
Basov, Bourell, Buerhop, Hahn, J. Lawrence, J.T. Spencer, Kurokawa, L. Li, Li, Sivakumar, Ueki, Yu   +11 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source