Results 31 to 40 of about 223,812 (206)
地球与行星物理论评High-precision and high-stability measurement is an essential approach for situational awareness of space targets, such as high-precision orbit determination, attitude determination, etc.
Mingliang Long +9 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Laser back scatter: Limitation to higher repetition rate [kHz] Satellite Laser Ranging system
Geodesy and Geodynamics, 2021 Satellite laser ranging (SLR) with higher repetition rate is the recent trend for its various advantages. Laser backscatter (coincidence between recently transmitted pulses and received pulses near the detector) is found to be a constraint for the ...
Farhat Iqbal +3 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Research on laser measuring device of surface displacements of mine roadway
Gong-kuang zidonghua, 2018 In view of problems of inconvenient measurement, time consuming, high labor intensity and uncontrollable errors of existing cross-measuring methods of surface displacements of mine roadway, a laser measuring device of surface displacements of mine ...
YE Meitu, LIANG Yiwei, WANG Kun
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Application of A Frequency Chirped RF Intensity Modulated 532 nm Light Source in Underwater Ranging
IEEE Photonics Journal, 2020 A radio-frequency (RF) intensity-modulated light source at 532 nm was built for underwater ranging. The intensity of a narrow-linewidth laser at 1064 nm was modulated via a Mach-Zehnder electro-optical modulator.
Kun Li +6 more
doaj +1 more source