Results 271 to 280 of about 26,542 (324)

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Non-invasive laser speckle contrast imaging (LSCI) of extra-embryonic blood vessels in intact avian eggs at early developmental stages. [PDF]

Biomed Opt Express
Dong Z, Mahler S, Readhead C, Chen X, Dickson M, Bronner M, Yang C.   +6 more
europepmc   +1 more source

Fast, high-density, and depth-sensitive time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow

Faraneh Fathi, Faezeh Akbari, Samaneh Rabienia Haratbar, Dara Singh, Mehrana Mohtasebi, Claudio Bruschini, Edoardo Charbon, Lei Chen, Guoqiang Yu   +8 more
openalex   +2 more sources

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Real-time quantification of laser speckle contrast imaging during intestinal laparoscopic surgery: successful demonstration in a porcine intestinal ischemia model. [PDF]

Surg Endosc
Hoffman JT, Heuvelings DJI, van Zutphen T, Stassen LPS, Kruijff S, Boerma EC, Bouvy ND, Heeman WT, Al-Taher M.   +8 more
europepmc   +1 more source

PEDOT:PSS—A Key Material for Bioelectronics

Advanced Science, EarlyView.
PEDOT:PSS ‐ Poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate ‐ is typically processed from water dispersions to form multifunctional and multidimensional constructs with tunable electronic and ionic conductivity. Throught processing engineering, PEDOT:PSS is intergrated in bioelectronic devices that operate efficiently in physiological conditions
Alan Eduardo Ávila Ramírez, David Pieter van der Laan, Mustafeez Bashir Shah, Liwen Wang, Erica Zeglio, Achilleas Savva   +5 more
wiley   +1 more source

Behavior‐ and Cell Type‐Specific Cortico‐Striatal Decoupling in a Parkinson's Disease‐Like Mouse Model

Advanced Science, EarlyView.
Utilizing dual‐site fiber photometry, this study examines cortico‐striatal coupling with cell type resolution, identifying behavior‐ and cell type‐specific cortico striatal decoupling and its dopamine‐dependent mechanism in a Parkinson's disease mouse model.
Xu‐Ran Yao, Yang Liu, Wei‐Tong Zheng, Mao‐Qing Huang, Kai‐Wen He   +4 more
wiley   +1 more source

Exploring the efficacy of laser speckle contrast imaging in the stratified diagnosis of rosacea: a quantitative analysis of facial blood flow dynamics across varied regions. [PDF]

Front Immunol
Liao JF, Jiang XM, Xie Z, Lei H, Luo J, Lv Y, Liu G, Mao Y, Song SY, Wang Y.   +9 more
europepmc   +1 more source

Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning

Advanced Science, EarlyView.
Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao, Guiyuan Shi, Ruixue Qin, Yinghao Sun, Wenbo Guo, Ruixia Shi, Minxian Peng, Jingxuan Yang, Jianjian Zhao, Qiuhan Liu, Jun Xiao, Ke Zhang, Qiang Liu, Wenxing Yang, He Liu   +14 more
wiley   +1 more source

NIR‐Triggered Upconversion‐Perovskite Heterostructures for Non‐Genetic, Implant‐Free Optoelectronic Neuromodulation

Advanced Science, EarlyView.
The Single‐Nanostructured Optoelectronic Vehicle for neuromodulation Activation (SNOVA) establishes a paradigm for non‐genetic, implant‐free neuromodulation. By integrating NIR‐excitable UCNPs with broadband‐absorbing perovskite QDs, SNOVA efficiently converts deeply penetrating light into localized electric fields that modulate neuronal ion dynamics ...
Luyue Jiang, Chenguang Ma, Yiping Zhao, Jiazhi Li, Gen Li, Shuang Jin, Haoyang Su, Ye Tian, Yingkang Yang, Yunfu Luo, Lei Huang, Peijie Chen, Yiming Gao, Yi Wei, Yike Xiang, Lunming Qin, Kaihuan Zhang, Yifei Ye, Pengyi Tang, Liuyang Sun   +19 more
wiley   +1 more source