Results 21 to 30 of about 2,510,910 (246)

Advanced methods for enhanced sensing in biomedical Raman spectroscopy [PDF]

, 2015
Raman spectroscopy is a powerful tool in the field of biomedicine for disease diagnosis owing to its potential to provide the molecular fingerprint of biological samples.
Balagopal, Bavishna
core   +1 more source

An open-path, hand-held laser system for the detection of methane gas [PDF]

, 2005
We have developed an open-path hand-held gas detector incorporating a distributed feedback InGaAs laser diode at 1.65 µm. Incorporated into a hand-held transceiver unit, the emitted laser beam is backscattered from nearby surfaces, collected and focused ...
Padgett, M, Murray, S, van Well, Ben, Gibson, G, Strzoda, Rainer, Padgett, Miles, van Well, B, Hodgkinson, Jane, Pride, Russ D., Murray, Stuart, Gibson, Graham, Strzoda, R, Pride, R, Hodgkinson, J   +13 more
core   +1 more source

Investigating Effects of Proteasome Inhibitor on Multiple Myeloma Cells Using Confocal Raman Microscopy

Sensors, 2016
Due to its label-free and non-destructive nature, applications of Raman spectroscopic imaging in monitoring therapeutic responses at the cellular level are growing.
Jeon Woong Kang, Surya P. Singh, Freddy T. Nguyen, Niyom Lue, Yongjin Sung, Peter T. C. So, Ramachandra R. Dasari   +6 more
doaj   +1 more source

Double face of cytochrome c in cancers by Raman imaging

Scientific Reports, 2022
Cytochrome c (Cyt c) is a key protein that is needed to maintain life (respiration) and cell death (apoptosis). The dual-function of Cyt c comes from its capability to act as mitochondrial redox carrier that transfers electrons between the membrane ...
H. Abramczyk, B. Brozek-Pluska, M. Kopeć   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

DFT-Based Design and Characterization of Organic Chromophores Based on Symmetric Thio-Bridge Quinoxaline Push–Pull (STQ-PP) for Solar Cells

Molecules
Organic solar cells require molecular materials with broad absorption and proper energy-level alignment to maximize photon harvesting and charge transport; in this context, this work focuses on the computational design and characterization of π ...
Edwin Rivera, Alex Garavis, Juan Garcia, Oriana Avila, Ruben Fonseca   +4 more
doaj   +1 more source

Impedance self-matching ultra-narrow linewidth fiber resonator by use of a tunable π-phase-shifted FBG

Scientific Reports, 2017
In this paper, we present a novel ultra-narrow linewidth fiber resonator formed by a tunable polarization maintaining (PM) π-phase-shifted fiber Bragg grating and a PM uniform fiber Bragg grating with a certain length of PM single mode fiber patch cable ...
Mingyong Jing, Bo Yu, Jianyong Hu, Huifang Hou, Guofeng Zhang, Liantuan Xiao, Suotang Jia   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source