Results 51 to 60 of about 504,415 (353)

Short-term efficacy of physical interventions in osteoarthritic knee pain. A systematic review and meta-analysis of randomised placebo-controlled trials. [PDF]

, 2007
BACKGROUND: Treatment efficacy of physical agents in osteoarthritis of the knee (OAK) pain has been largely unknown, and this systematic review was aimed at assessing their short-term efficacies for pain relief.
A Andrianakos, A Fargas-Babjak, A Gur, A Khadilkar, A Molsberger, A White, AF Shaughnessy, Anne E Ljunggren, AR Jadad, AS Quirk, B Hegedus, B Lewis, B Nivbrant, BM Berman, Bård Bogen, C Sangdee, C Witt, CJ Derry, CR Smith, D Carroll, D Lewis, DH Trock, DH Trock, DJ Hunter, DT Felson, E Naredo, EM Roos, ES Pessoa, EW Ehrich, F Angst, F Song, F Tubach, GL Cheing, H Jensen, HH Dubben, J Low, J Stelian, J Vas, Jan M Bjordal, JB Walker, JH Kellgren, JM Bjordal, JM Bjordal, JM Bjordal, JM Bjordal, JM Bjordal, JM Bjordal, JP Ioannidis, K Grimmer, K Ishimaru, KA Sluka, KD Brandt, KG Baker, KM Jordan, KM Jordan, L Brosseau, L Chesterton, M Egger, M Osiri, M Yurtkuran, M Yurtkuran, Mark I Johnson, MI Johnson, MJ Smith, MJA Klaber, MP Steultjens, N Bellamy, N Bellamy, N Pipitone, N Wiebe, P Barlas, P Nicolakis, P Taylor, P White, PM Bulow, PM Peloso, PP Law, R Defrin, R Lubart, Roberta Chow, Rodrigo AB Lopes-Martins, S Götte, SM Cowan, T Harlow, VJ Robertson, W Takeda, World Association for Laser Therapy - WALT   +86 more
core   +5 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Use of Ranibizumab for evaluating focal laser combination therapy for refractory diabetic macular edema patients: an exploratory study on the RELAND trials

Scientific Reports, 2023
Anti-vascular endothelial growth factor (VEGF) therapy is the first-line treatment for diabetic macular edema (DME), but is less effective in some patients.
Makoto Hatano, Makiko Wakuta, Kazutaka Yamamoto, Eika Arai, Miho Enoki, Kazushi Fujimoto, Kazuhiko Yamauchi, Keijiro Ishikawa, Koh-Hei Sonoda, Kazuhiro Kimura   +9 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Laser in Clinical Ophthalmology: Possible Applications, Limitations, and Hazards [PDF]

, 1965
The present status of laser application in clinical ophthalmology is discussed. The differences between conventional light coagulator characteristics and those of presently available ruby lasers for clinical use are compared.
Geeraets, Walter J.
core   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice [PDF]

, 2013
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH).
Arai, Ken, Cianchetti, Flor A., Fan, Xiang, Förch, Christian, Lauer, Arne, Leyen, Klaus van, Lo, Eng H., Mandeville, Emiri, Rosidi, Nathanael L., Schaffer, Chris B., Schlunk, Frieder, Steinmetz, Helmuth, Wang, Xiaoying, Yigitkanli, Kazim   +13 more
core   +6 more sources

Photobiomodulation in the management of oral mucositis for adult head and neck cancer patients receiving irradiation: the LiTEFORM RCT

Health Technology Assessment, 2022
Background: Oral mucositis is a debilitating and painful complication of head and neck cancer irradiation that is characterised by inflammation of the mucous membranes, erythema and ulceration.
Michael Nugent, Valerie Bryant, Chrissie Butcher, Holly Fisher, Sean Gill, Rebecca Goranova, Shaun Hiu, Lyndsay Lindley, James O’Hara, Yemi Oluboyede, Joanne Patterson, Tim Rapley, Tomos Robinson, Nikki Rousseau, Vicky Ryan, Ramkumar Shanmugasundaram, Linda Sharp, Ruby Smith Whelan, Deborah D Stocken, Laura Ternent, Janet Wilson, Jenn Walker   +21 more
doaj   +1 more source

THE EFFICACY OF LASER THERAPY AND IBUPROFEN ON PAIN AFTER ELASTOMERIC SEPARATOR PLACEMENT: RAPID REVIEW

ODONTO: Dental Journal, 2021
Background: Separator placement is the first step in orthodontic treatment, which aims to create space between teeth before molar band placement. This procedure can cause pain for the patient. Pain management after separator placement can be done through
Regina Yosephine Simarmata, Ida Ayu Evangelina, Avi Laviana, Endah Mardiati   +3 more
doaj   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source