Results 51 to 60 of about 9,002,875 (302)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Sensors, 2020 Laser lights have been used by dermatologists for tattoo removal through photothermal interactions. However, most clinical studies used a visual scoring method to evaluate the tattoo removal process less objectively, leading to unnecessary treatments ...
Myeongjin Kim +3 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Laser Applications on Iris for Treatment of Glaucoma
, 2013 Laser applications on iris for the treatment of glaucoma include laser iridotomy (LI) and laser peripheral iridoplasty (LPI). LI is a simple and effective modality for treatment of closed-angle glaucoma with pupillary block. LPI is an easy and effective
Ahmet Özkök +7 more
core +1 more source
Investigation into laser re-melting of inconel 625 HVOF coating blended with WC [PDF]
, 2009 High velocity oxy-fuel (HVOF) spraying of Diamalloy 1005 powders mixed with WC particles onto steel (304) is considered and laser re-melting of the resulting coatings is examined.
Al-Taha, Zuhair Y.
core +2 more sources
Liquation and post-weld heat treatment cracking in Rene 80 laser repair welds [PDF]
, 2012 An extensive experimental study on a nickel-based superalloy, Rene 80 using autogenous laser welding has been undertaken to determine the effect of the process parameters and weld bead geometry on cracking in the as-welded and post- weld heat treated ...
Colegrove, Paul A. +7 more
core +1 more source
Surface modification techniques for zirconia-based bioceramics: A review
Journal of Pharmacy and Bioallied Sciences, 2019 Zirconia is gaining interest as a ceramic biomaterial for implant applications due to its biocompatibility and desirable mechanical properties. At present, zirconia-based bioceramics is often seen in the applications of hip replacement and dental ...
Suma Karthigeyan +5 more
doaj +1 more source
Journal of Dermatology and Dermatologic Surgery, 2023 Background: Hirsutism is the excessive body or facial terminal (coarse) hair growth in females in a male-like pattern, carries a worldwide prevalence of 5%–20%, and requires careful evaluation and long-term management.
Malak H Aldosari +7 more
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Laser smoothing of binary gratings and multilevel etched structures in fused silica [PDF]
, 2010 We describe a promising approach to the processing of micro-optical components, where CO2 laser irradiation in raster scan is used to generate localized surface melting of binary or multilevel structures on silica, fabricated by conventional reactive-ion
Wlodarczyk, Krystian Lukasz +9 more
core +1 more source