Results 71 to 80 of about 19,763 (266)

Estudo comparativo de simulações paleoclimáticas na região do Atlântico Sul Comparison of paleoclimatics simulation in the South Atlantic region

Revista Brasileira de Meteorologia, 2007
Neste estudo são comparadas diferentes simulações de modelos paleoclimáticos para duas épocas distintas, o Último Máximo Glacial (UMG) e o Presente.
Adriana Oliveira, Gagriel Clauzet, Ilana Wainer   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Human Occupation of the Central Balkans During the Last Glacial Maximum: Evidence from Serbia

Quaternary
This paper presents archeological data and chronometric dates documenting human presence in Serbia, central Balkans, during MIS 2. We describe findings from excavations at three cave sites and dating results from two additional localities.
Steven Kuhn, Dušan Mihailović, Slobodan Marković, Zoran M. Perić, Sofija Dragosavac, Marija Stojković, Mirjana Roksandic   +6 more
doaj   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Ecology of large ungulates in the northeastern Iberian Peninsula during the Upper Palaeolithic through stable isotopes and tooth wear analysis

Quaternary Environments and Humans
The northeastern Iberian Peninsula acted as a refuge zone during the Late Pleistocene where the persistence of terrestrial ecosystems could provide hunter-gatherers with large prey, mainly horse (Equus ferus) and red deer (Cervus elaphus). Isotopic (δ13C,
Dorothée G. Drucker, Florent Rivals, Jordi Nadal, Isaac Rufí, Joaquim Soler, Narcís Soler, Julià Maroto   +6 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Simulated changes in aridity from the last glacial maximum to 4xCO2

Environmental Research Letters, 2017
Aridity is generally defined as the ‘degree to which a climate lacks moisture to sustain life in terrestrial ecosystems’. Several recent studies using the ‘aridity index’ (the ratio of potential evaporation to precipitation), have concluded that aridity ...
Peter Greve, Michael L Roderick, Sonia I Seneviratne   +2 more
doaj   +1 more source

Microrefugia and species persistence in the Galápagos highlands: A 26,000-year paleoecological perspective.

Frontiers in Genetics, 2013
The Galápagos Islands are known to have experienced significant drought during the Quaternary. The loss of mesophytic upland habitats has been suggested to underlie the relatively lower endemism of upland compared with lowland plant assemblages.
Aaron F Collins, Mark B Bush, Julian P Sachs   +2 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source