Results 91 to 100 of about 160,902 (289)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Ice age unfrozen: severe effect of the last interglacial, not glacial, climate change on East Asian avifauna

BMC Evolutionary Biology, 2017
Background The glacial-interglacial cycles in the Pleistocene caused repeated range expansion and contraction of species in several regions in the world.
Feng Dong, Chih-Ming Hung, Xin-Lei Li, Jian-Yun Gao, Qiang Zhang, Fei Wu, Fu-Min Lei, Shou-Hsien Li, Xiao-Jun Yang   +8 more
doaj   +1 more source

Indian monsoon variability on millennial-orbital timescales [PDF]

, 2016
The Indian summer monsoon (ISM) monsoon is critical to billions of people living in the region. Yet, significant debates remain on primary ISM drivers on millennial-orbital timescales.
Breitenbach, Sebastian, Cai, Yanjun, Cheng, Hai, Edwards, R. Lawrence, Kathayat, Gayatri, Li, Xianglei, Lui, Weiguo Lui, Ning, Youfeng, Sinha, Ashish, Spötl, Christoph, Yi, Liang, Zhang, Haiwei   +11 more
core   +3 more sources

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Radiocarbon evidence for enhanced respired carbon storage in the Atlantic at the Last Glacial Maximum [PDF]

The influence of ocean circulation changes on atmospheric CO2 hinges primarily on the ability to alter the ocean interior's respired nutrient inventory.
Freeman, E., Hodell, D., Skinner, L. C., Waelbroeck, C.   +3 more
core   +1 more source

The northern sector of the last British ice sheet : maximum extent and demise [PDF]

, 2008
Strongly divided opinion has led to competing, apparently contradictory, views on the timing, extent, flow configuration and decay mechanism of the last British Ice Sheet.
Bradwell, Tom, Stoker, Martyn, Golledge, Nicholas, Wilson, Christian Kverneland, Merritt, Jon, Long, David, Everest, Jeremy, Hestvik, O.B., Stevenson, Alan, Hubbard, Alun, Finlayson, Andrew, Mathers, Hannah   +11 more
core   +2 more sources

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Slow Dynamics of Hydrate Systems Revealed by a Double BSR

Geophysical Research Letters
Determining how gas hydrate distribution evolved along continental margins in the past is essential to understanding its evolution in the future. Moreover, hydrate decomposition has been linked to several catastrophic events, including some of the ...
M. Fabre, V. Riboulot, L. Loncke, S. Ker, G. Ballas, Y. Thomas, G. Ion, N. Sultan   +7 more
doaj   +1 more source

Modeling of the northern hemisphere ice sheets during the last glacial cycle and glaciological sensitivity [PDF]

, 2005
We present a new three-dimensional thermomechanically coupled ice sheet model of the northern hemisphere to reconstruct the Quaternary ice sheets during the last glacial cycle.
Huybrechts, Philippe, Zweck, C.
core   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source