Results 71 to 80 of about 160,902 (289)

Landscape genetics reveal broad and fine‐scale population structure due to landscape features and climate history in the northern leopard frog (Rana pipiens) in North Dakota [PDF]

, 2018
Prehistoric climate and landscape features play large roles structuring wildlife populations. The amphibians of the northern Great Plains of North America present an opportunity to investigate how these factors affect colonization, migration, and current
Fisher, Justin D.L., Mushet, David M., Purcell, Kevin, Stockwell, Craig A., Waraniak, Justin M.   +4 more
core   +1 more source

The environmental and evolutionary history of Lake Ohrid (FYROM/Albania). Interim results from the SCOPSCO deep drilling project [PDF]

, 2016
This study reviews and synthesises existing information generated within the SCOPSCO (Scientific Collaboration on Past Speciation Conditions in Lake Ohrid) deep drilling project.
Addabbo, Michele, Albrecht, Christian, Anna M., Baumgarten, Henrike, Bertini, Adele, Combourieu Nebout, Nathalie, Cvetkoska, Aleksandra, Dapos, Donders, Föller, Kirstin, Francke, Alexander, George A., Giaccio, Biagio, Grazhdani, Andon, Hauffe, Torsten, Holtvoeth, Jens, Jack H., Joannin, Sebastien, Jovanovska, Elena, Just, Janna, Kouli, Katerina, Koutsodendris, Andreas, Krastel, Sebastian, Lacey, Leicher, Niklas, Leng, Levkov, Zlatko, Lindhorst, Katja, Masi, Alessia, Melanie J., Mercuri, Nomade, Sebastien, Nowaczyk, Norbert, Panagiotopoulos, Konstantinos, Peyron, Odile, Reed, Jane M., REGATTIERI, ELEONORA, Sadori, Laura, Sagnotti, Leonardo, Stelbrink, Björn, Sulpizio, Roberto, Timme H., Tofilovska, Slavica, Torri, Paola, Vogel, Hendrik, Wagner Cremer, Friederike, Wagner, Bernd, Wagner, Thomas, Wilke, Thomas, Wolff, Wonik, Thomas, ZANCHETTA, GIOVANNI, Zhang, Xiaosen S.   +52 more
core   +14 more sources

Increase in atmospheric carbonyl sulphide since the last glacial period

, 2023
Abstract Carbonyl sulphide (COS) is the most abundant atmospheric sulphur gas with links to terrestrial and oceanic productivity1. A 52,000-year COS record was recovered from a South Pole ice core. We find evidence for COS production in the ice sheet that alters the atmospheric signal in the ice but can be corrected for using sea salt sodium as
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Geochronological reconstruction of the glacial evolution in the Ésera valley (Central Pyrenees) during the Late Pleistocene and Holocene [PDF]

Climate of the Past
Since the MIS (Marine Isotope Stage) 4, glaciers in the Pyrenees were subject to intricate dynamics, encompassing some advances and retreats not always aligned with the fluctuations observed in other European glaciers.
I. Vidaller, T. Fujioka, J. I. López-Moreno, A. Moreno   +3 more
doaj   +1 more source

Impact of millennial-scale oceanic variability on the Greenland ice-sheet evolution throughout the last glacial period [PDF]

Climate of the Past, 2019
Temperature reconstructions from Greenland ice-sheet (GrIS) ice cores indicate the occurrence of more than 20 abrupt warmings during the last glacial period (LGP) known as Dansgaard-Oeschger (D-O) events.
I. Tabone, I. Tabone, A. Robinson, A. Robinson, A. Robinson, J. Alvarez-Solas, J. Alvarez-Solas, M. Montoya, M. Montoya   +8 more
doaj   +1 more source

Northeastern Atlantic benthic foraminifera during the last 45,000 years: Changes in productivity seen from the bottom up [PDF]

, 1995
We studied benthic foraminifera from the last 45 kyr in the >63 mu m size fraction in Biogeochemical Ocean Flux Studies (BOFS) cores 5K (50 degrees 41.3'N, 21 degrees 51.9'W, depth 3547 m) and 14K (58 degrees 37.2'N, 19 degrees 26.2'W, depth 1756 m), at ...
Booth, L, Maslin, M, Shackleton, NJ, Thomas, E   +3 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Reconciling diverse lacustrine and terrestrial system response to penultimate deglacial warming in southern Europe [PDF]

, 2015
Unlike the most recent deglaciation, the regional expression of climate changes during the penultimate deglaciation remains understudied, even though it led into a period of excess warmth with estimates of global average temperature 1–2 °C, and sea level
Frogley, Michael R, Hughes, Philip D, Reed, Jane M, Tzedakis, Polychronis C, Wilson, Graham P   +4 more
core   +3 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source