Results 61 to 70 of about 160,902 (289)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Lower Glacial Oxygen in the Eastern Equatorial Pacific Concentrated in the Deep Sea

Geophysical Research Letters
Oxygen in the global oceans has declined since the 1960s, including in the Eastern Equatorial Pacific (EEP). Reconstructions of EEP glacial oxygenation help advance understanding of current and projected ocean deoxygenation.
Wanyi Lu, Delia W. Oppo, Xiaoying Jiang, Haowen Dang, Zhimin Jian   +4 more
doaj   +1 more source

Ice Core Records of Antarctic Warming Events in the Last Glacial Period [PDF]

, 2016
第3回極域科学シンポジウム　横断セッション「海・陸・氷床から探る後期新生代の南極寒冷圏環境変動」11月26日（月） 国立国語研究所 ...
Hideaki Motoyama, Kenji Kawamura, Kumiko Goto-Azuma, Motohiro Hirabayashi, Ryu Uemura, Shuji Fujita, Takayuki Kuramoto, Takayuki Miyake, Takuya Tatenuma   +8 more
core   +1 more source

Quaternary glacial evolution in the Central Cantabrian Mountains (Northern Spain) [PDF]

, 2012
Peer ...
González-García, M., González-Trueba, J.J., Gómez-Lende, M., Pellitero, R., Serrano, E.   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Discharge of Meteoric Water in the Eastern Norwegian Sea since the Last Glacial Period

Geophysical Research Letters, 2019
Submarine groundwater discharge could impact the transport of critical solutes to the ocean. However, its driver(s), significance over geological time scales, and geographical coverage are poorly understood.
Wei‐Li Hong, Aivo Lepland, Tobias Himmler, Ji‐Hoon Kim, Shyam Chand, Diana Sahy, Evan A. Solomon, James W. B. Rae, Tõnu Martma, Seung‐Il Nam, Jochen Knies   +10 more
doaj   +1 more source

Calcite covering of sediment as a possible way of curbing blue-green algae [PDF]

, 1992
Natural calcite precipitation in lakes is a well-known control mechanism of eutrophication. In hard-water lakes, calcite deposits on the flat bottoms of shallow lakes and near the shores of deeper lakes resulted from biogenic decalcification during the ...
Klapper, H.
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Evolution of the Great Tehuelche Paleolake in the Torres del Paine National Park of Chilean Patagonia during the Last Glacial Maximum and Holocene [PDF]

, 2012
Indexación: Web of Science; ScieloRESUMEN. Una serie de morrenas glaciares se distribuyen desde el margen oriental de la cuenca de drenaje Torres del Paine a cerca del actual margen de los Campos de Hielo Patagónico, junto con una serie de terrazas ...
Airo, Alessandro, Calderón, Mauricio, Hervé, Francisco, Le Roux, Jacobus P., Solari, Marcelo A.   +4 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source