Results 51 to 60 of about 160,902 (289)

Progress in paleoclimate modeling [PDF]

, 2006
International audienceThis paper briefly surveys areas of paleoclimate modeling notable for recent progress. New ideas, including hypotheses giving a pivotal role to sea ice, have revitalized the low-order models used to simulate the time evolution of ...
AchutaRao, Allen, Alley, Alley, Amy Clement, Ashkenazy, Ashkenazy, Barber, Bassinot, Benzi, Bjerknes, Bjerknes, Bond, Bond, Braconnot, Braconnot, Braconnot, Briffa, Broecker, Calov, Cane, Chapman, Clark, Clement, Collins, Collins, Cortijo, Cortijo, Crowley, Crucifix, Dansgaard, DeNoblet, Didier Paillard, Dong, Eduardo Zorita, Elkibbi, Esper, Esper, Fine, Gagan, Gallimore, Ganapolski, Ganopolski, Ganopolski, Ghil, Gildor, Gildor, Gildor, Gildor, Gildor, Gildor, Gildor, Gordon, Gu, Harrison, Harrison, Haug, Hewitt, Hezi Gildor, Hoerling, Houghton, Imbrie, Imbrie, Jones, Jost, Joussaume, Kageyama, Kageyama, Kageyama, Karner, Keeling, Kennett, Khodri, Khodri, Kim, Kitoh, Kitoh, Kohfeld, Källén, Lambeck, Latif, Le-Treut, Lean, Levis, Liu, Liu, Liu, Lu, Luterbacher, MacAyeal, Mahowald, Mann, Mann, Mark A. Cane, Masa Kageyama, McGlone, McManus, Milankovitch, Mitchell, Mix, Moy, Muller, Myriam Khodri, Oerlemans, Oppo, Osborn, Otto-Bliesner, Otto-Bliesner, Paillard, Paillard, Paillard, Paillard, Paillard, Parrenin, Pascale Braconnot, Pelletier, Peterson, Petit, Pinot, Pons, Pope, Prange, Rahmstorf, Rajagopalan, Rittenour, Rodbell, Rodgers, Rodgers, Roe, Saltzman, Saltzman, Saltzman, Saltzman, Sandweiss, Sandweiss, Sayag, Schmittner, Schulz, Shackleton, Shackleton, Shin, Shin, Shulmeister, Simon Tett, Stott, Stott, Sylvie Joussaume, Sànchez-Goñi, Tarasov, Tarasov, Tett, Tett, Timmermann, Trenberth, Tsimring, Tudhope, Tzedakis, Vettoretti, von Storch, Wang, Wang, Weaver, Weaver, Williams, Wohlfahrt, Wunsch, Zebiak, Zhao, Zorita   +168 more
core   +4 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Origin and significance of ice‐rafted detritus in the Atlantic sector of the Southern Ocean

Geochemistry, Geophysics, Geosystems, 2007
Piston core TN057‐14 from the eastern Atlantic sector of the Southern Ocean contains several layers rich in volcanic tephra that were deposited during the last glacial period.
Simon H. H. Nielsen, D. A. Hodell, G. Kamenov, T. Guilderson, M. R. Perfit   +4 more
doaj   +1 more source

North Atlantic abrupt climatic events of the last glacial period recorded in Ukrainian loess deposits [PDF]

Climate of the Past, 2011
Loess deposits are widely distributed in the Northern Hemisphere, where they have recorded not only the glacial-interglacial cycles, but also millennial-timescale changes resembling those in marine and ice cores. Such abrupt variations are clearly marked
D.-D. Rousseau, P. Antoine, N. Gerasimenko, A. Sima, M. Fuchs, C. Hatté, O. Moine, L. Zoeller   +7 more
doaj   +1 more source

Deep-water coral records of glacial and recent ocean-atmosphere dynamics from the Perth Canyon in the southeast Indian Ocean

Quaternary Science Advances, 2022
We present radiocarbon and neodymium isotope records from accurately dated (U-series) live and fossil (
Julie A. Trotter, Malcolm T. McCulloch, Juan Pablo D'Olivo, Pete Scott, Nadine Tisnérat-Laborde, Marco Taviani, Paolo Montagna   +6 more
doaj   +1 more source

Productivity patterns in the Equatorial Pacific over the last 30,000 years [PDF]

, 2017
The equatorial Pacific traverses a number of productivity regimes, from the highly productive coastal upwelling along Peru to the near gyre-like productivity lows along the international dateline, making it an ideal target for investigating how ...
Anderson, Robert F., Costa, Kassandra M., Jacobel, Allison W., McManus, Jerry F., Thiagarajan, Nivedita, Winckler, Gisela   +5 more
core   +1 more source

The transition from the Last Glacial Period in inland and near‐coastal Antarctica [PDF]

Geophysical Research Letters, 2000
Recent studies suggested that, during the transition out of the last glacial period, one near‐coastal site in Antarctica showed a response similar to that of Greenland, and unlike that of central Antarctica. Here, we present a new high‐resolution record of calcium from Dome C, Antarctica.
Mulvaney, R., Rothlisberger, R., Wolff, E.W., Sommer, S., Schwander, J., Hutterli, M.A., Jouzel, J.   +6 more
openaire   +5 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

100- kyr cyclicity in volcanic ash emplacement: evidence from a 1.1 Myr tephra record from the NW Pacific [PDF]

, 2018
It is a longstanding observation that the frequency of volcanism periodically changes at times of global climate change. The existence of causal links between volcanism and Earth's climate remains highly controversial, partly because most related studies
Freundt, Armin, Jegen, Marion, Kutterolf, Steffen, McManus, Jerry F., Mleneck-Vautravers, Maryline J., Schindlbeck, Julie Christin, Straub, Susanne M.   +6 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source